Results 131 to 140 of about 30,366 (254)

Variability in competitive fitness among environmental and clinical azole-resistant Aspergillus fumigatus isolates

mBio
Azoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen, Guoxing Zhu, Huiping Lin, Jian Guo, Shuwen Deng, Wenjuan Wu, Gustavo H. Goldman, Ling Lu, Yuanwei Zhang   +8 more
doaj   +1 more source

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Exploration of novel mechanisms of azole resistance in Candida auris. [PDF]

Candida auris is a pathogenic yeast of particular concern because of its ability to cause nosocomial outbreaks of invasive candidiasis (IC) and to develop resistance to all current antifungal drug classes. Most C. auris clinical isolates are resistant to
Brandalise, D., Coste, A.T., Lamoth, F., Li, J., Sanglard, D.   +4 more
core   +1 more source

Bisphosphonates synergistically enhance the antifungal activity of azoles in dermatophytes and other pathogenic molds

mSphere
Superficial infections of the skin, hair, and nails by fungal dermatophytes are the most prevalent of human mycoses, and many infections are refractory to treatment. As current treatment options are limited, recent research has explored drug synergy with
Aidan Kane, Joanna G. Rothwell, Annabel Guttentag, Steven Hainsworth, Dee Carter   +4 more
doaj   +1 more source

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

Synthesis and Biological Evaluation of β-Phenylalanine Derivatives Containing Sulphonamide and Azole Moieties as Antiproliferative Candidates in Lung Cancer Models

Molecules
In this study, a series of novel β-phenylalanine derivatives were synthesised and evaluated for their anticancer activity. The 3-(4-methylbenzene-1-sulfonamido)-3-phenylpropanoic acid (2) was prepared using β-phenylalanine as a core scaffold. The β-amino
Vytautas Mickevičius, Kazimieras Anusevičius, Birutė Sapijanskaitė-Banevič, Ilona Jonuškienė, Linas Kapočius, Birutė Grybaitė, Ramunė Grigalevičiūtė, Povilas Kavaliauskas   +7 more
doaj   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Impact of the use of azole fungicides, other than as human medicines, on the development of azole-resistant Aspergillus spp. [PDF]

The use of azoles in the European Union and European Economic Area (EU/EEA) other than as human medicines has raised concerns about emergence and spread of azole-resistant Aspergillus species.
EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ., European Environment Agency (EEA), EUROPEAN FOOD SAFETY AUTHORITY ., European Chemicals Agency (ECHA), EUROPEAN ENVIRONMENT AGENCY (EEA) ., EUROPEAN COMMISSION Joint Research Centre, European Commission's Joint Research Centre (JRC), EUROPEAN MEDICINES AGENCY ., EUROPEAN CHEMICALS AGENCY ., European Medicines Agency (EMA), European Food Safety Authority (EFSA), European Centre for Disease Prevention and Control (ECDC)   +11 more
core   +1 more source

Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata

Microbiology Spectrum
Fungal infections affect over 6.55 million individuals annually, with Candida glabrata (recently reclassified as Nakaseomyces glabratus) being the second most common cause of invasive candidiasis and candidemia, conditions that carry a high mortality ...
Catrin C. Williams, Jane Usher
doaj   +1 more source

Azole‐Based Diarylbenzenes for Molecular Solar Thermal Energy Storage: A Computational Analysis

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Diarylethenes containing aromatic π‐linkers have attracted research interest in recent years owing to their potential applications in molecular solar thermal (MOST) energy storage systems. In this work, we demonstrate that replacing the thienyl core of diarylbenzenes with an oxazole core and introducing lateral alkyl‐substituents on the oxazole core ...
Thillaiarasi Sukumar, M. V. R. Akshay Sampath, D. Bala Karuna Kumar, Bhagyashri Devaru Bhat, Mahesh Kumar Ravva, Baswanth Oruganti   +5 more
wiley   +1 more source