Results 111 to 120 of about 30,341 (234)

Computational Design of Azole Derivatives as Multifunctional Agents for Alzheimer's Disease

Applied Organometallic Chemistry, Volume 40, Issue 5, May 2026.
A series of 19 azole derivatives were evaluated using bioinformatic tools and density functional theory in the context of multifunctional agents for Alzheimer's disease and were classified as potential antioxidant, distributor, and suppressor agents. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, characterized by multifactorial ...
Nicolás Puentes‐Díaz, Yair Alvarez‐Ricardo, Diego Chaparro, Areli Flores‐Gaspar, John Hurtado, Jorge Alí‐Torres   +5 more
wiley   +1 more source

Laryngeal Transplantation in Cancer Patients: Evaluation of Surgical Outcomes and Functional Recovery

MedComm, Volume 7, Issue 5, May 2026.
Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang, Mailudan Ainiwaer, Pengwei Zhao, Yansheng Hu, Xin Yang, Yu Xiong, Bin Zeng, Longhao Wang, Jun Liu, Fei Chen   +9 more
wiley   +1 more source

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 952-964, May 2026.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

An integrated social and natural sciences case study for the reuse of organic wastes as soil amendments

PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 965-982, May 2026.
Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder, Jose‐Luis Fajardo‐Escoffié, Laura Carter, Emily K. Durant, Katie J. Field, John Nightingale, Brett Sallach, Andrea‐Lorena Garduño‐Jiménez   +7 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources

Fungal colonization in Cystic Fibrosis (CF): Epidemiology and antifungal resistance in a French cohort of CF patients – Focused on Aspergillus fumigatus colonization [PDF]

, 2011
Introduction: Cystic fibrosis (CF) is the major genetic inherited disease in the European Caucasian population, with an average of 1 in 3000 living births in France. Prognostic depend essentially on the lung impairments.
A. Fanton, A. Farce, B. Wallaert, C. Llerana, C. Person, C. Pinel, E. Fréalle, G.A. Loeuille, I. Accoceberry, I. Durand-Joly, J.P. Bouchara, L. Delhaès, L. Favennec, M. d\u27Almeida-Fourquet, O. Vagner, P. Chavatte, P. Domblides, S. Dominique, S. Leroy   +18 more
core   +1 more source

Mechanisms of resistance to azole antifungals.

Acta Biochimica Polonica, 1995
Until the late eighties, clinical resistance to azole antifungals was a rare phenomenon. Only a few cases of resistance to ketoconazole were found in patients with chronic mucocutaneous candidiasis (CMC). The spread of AIDS and the widespread prophylactic and therapeutic use of the hydrophilic azole compound fluconazole resulted both in the selection ...
P, Marichal, H, Vanden Bossche
openaire   +3 more sources

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 792-810, May 2026.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter, Evyatar Ben Mordechay, Benny Chefetz, Zeyou Chen, Xinyi Cui, Jay Gan, Hui Li, Audrey Moores, Xiaoyu Gao   +8 more
wiley   +1 more source

Biofilm Formation and Aspartyl Proteinase Activity and Their Association with Azole Resistance Among Candida albicans Causing Vulvovaginal Candidiasis, Egypt

Infection and Drug Resistance, 2023
Marian A Gerges,1 Yasmin Ahmed Fahmy,1 Thoraya Hosny,2 Nessma H Gandor,2 Sherif Y Mohammed,2 Tahia Mohamed Ahmed Mohamed,2 Nabila Elsayed Mousa Abdelmoteleb,3 Noura E Esmaeel1 1Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig ...
Gerges MA, Fahmy YA, Hosny T, Gandor NH, Mohammed SY, Mohamed TMA, Abdelmoteleb NEM, Esmaeel NE   +7 more
doaj  

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis [PDF]

, 2017
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds.
Ana C. A. de Paula e Silva, Ana M. Fusco-Almeida, Caroline B. Costa-Orlandi, Caroline M. Marcos, Haroldo C. de Oliveira, Liliana Scorzoni, Maria J. S. Mendes-Giannini, Patrícia A. Assato, Wanessa C. M. A. de Melo   +8 more
core   +1 more source