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Divergent mitochondrial responses and metabolic signal pathways secure the azole resistance in Crabtree-positive and negative Candida species. [PDF]

Microbiol Spectr
Zhou M, Peng J, Ren K, Yu Y, Li D, She X, Liu W.   +6 more
europepmc   +1 more source

Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance. [PDF]

Commun Biol
He X, Kusuya Y, Hagiwara D, Toyotome T, Arai T, Bian C, Nagayama M, Shibata S, Watanabe A, Takahashi H.   +9 more
europepmc   +1 more source

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Azole Resistance in Candida glabrata

Current Infectious Disease Reports, 2016
Candida infections have increased due to the growth and expansion of susceptible patient populations. The azole fluconazole is the most widely prescribed antifungal, but rising rates of clinical resistance among Candida glabrata isolates have greatly limited its utility.
Sarah G, Whaley, P David, Rogers
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Azole resistance inCandida albicans

Medical Mycology, 1984
Two isolates of Candida albicans from chronic mucocutaneous candidosis patients who initially responded to ketoconazole treatment but who later relapsed, have shown an abnormal response to ketoconazole in four out of five systems in vitro and in three animal models of vaginal or systemic infection. They have also shown abnormal resistance to inhibition
J F, Ryley, R G, Wilson, K J, Barrett-Bee   +2 more
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Emergence of Azole Resistance in Aspergillus

Seminars in Respiratory and Critical Care Medicine, 2015
Resistance to the azole antifungals itraconazole, voriconazole, and posaconazole in Aspergillus species is a growing concern. This is especially alarming for A. fumigatus, where acquired resistance has been documented in patients with invasive disease caused by this species that were exposed to these agents, as well as in azole-naive individuals.
Nathan P, Wiederhold, Thomas F, Patterson   +1 more
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Azole resistance inCandida albicans

Medical Mycology, 1986
An isolate of Candida albicans from a patient with chronic mucocutaneous candidosis who relapsed during ketoconazole treatment was compared with a number of other azole-sensitive and azole-resistant isolates by tests in vitro and in three animal models of vaginal or disseminated infection.
K J, Smith, D W, Warnock, C T, Kennedy, E M, Johnson, V, Hopwood, J, Van Cutsem, H, Vanden Bossche   +6 more
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Azole-resistant aspergillosis

Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
openaire   +2 more sources

Multi-azole resistance in Aspergillus fumigatus

International Journal of Antimicrobial Agents, 2006
Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole.
Howard, Susan J., Webster, Ian, Moore, Caroline B., Gardiner, Rebecca E., Park, Steven, Perlin, David S., Denning, David W.   +6 more
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Azole Antifungal Resistance Today: Focus on Aspergillus

Current Infectious Disease Reports, 2011
Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European locations, in China, Canada and the ...
Bowyer, Paul, Moore, Caroline B., Rautemaa-Richardson, Riina, Denning, David W., Richardson, Malcolm   +4 more
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Assessment of Azole Resistance in Healthcare Facilities

2021
Azole resistance among fungal species has been increasing worldwide in recent years, representing a public health concern in the management of fungal infections. The complex environment of healthcare facilities, where microbial agents, including fungal contamination, are present must be controlled in order to protect susceptible patients. In this study,
Caetano, Liliana Aranha, Costa, Natália, Oliveira, Cátia   +2 more
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