Pharmacovigilance analysis of myopathy associated with azoles and nonstatins interactions based on US FAERS database [PDF]
Scientific ReportsAzoles are first-line antifungal agents known to increase the risk of statin-related myopathy due to drug interactions. However, myopathy events have also been observed in patients using azoles without concurrent statin use, suggesting that azoles may be
Shen’ao Jing +8 more
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Impact of concomitant azoles on ruxolitinib treatment in patients with GVHD: post hoc analyses of REACH2 and REACH3 [PDF]
Blood Advances: Azole antifungal agents, commonly used for preventing invasive fungal infections in graft-versus-host disease (GVHD), are known to affect ruxolitinib metabolism.
Zahra Mahmoudjafari +6 more
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Diazocarbonyl and Related Compounds in the Synthesis of Azoles
Molecules, 2021 Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo chemistry is the preparation of azoles from diazo compounds.
Anton Budeev +3 more
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Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones
Molecules, 2023 A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction proceeded under mild and transition metal-free conditions through an addition/elimination cascade ...
Martina Palomba +5 more
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In Vitro and In Vivo Interactions of TOR Inhibitor AZD8055 and Azoles against Pathogenic Fungi
Microbiology Spectrum, 2022 In the present study, in vitro and in vivo interactions of TOR inhibitor AZD8055 and azoles, including itraconazole, voriconazole, posaconazole and fluconazole, against a variety of pathogenic fungi were investigated.
Yi Sun +5 more
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Azole Use in Agriculture, Horticulture, and Wood Preservation – Is It Indispensable?
Frontiers in Cellular and Infection Microbiology, 2021 Plant pathogens cause significant damage to plant products, compromising both quantities and quality. Even though many elements of agricultural practices are an integral part of reducing disease attacks, modern agriculture is still highly reliant on ...
Lise Nistrup Jørgensen +1 more
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Épidémiologie des candidoses systémiques dans les services à haut risque au CHU et au centre anti cancer de Batna –Algérie. [PDF]
Batna Journal of Medical Sciences, 2022 Background: Systemic candidiasis are serious conditions responsible for high mortality. The objective of this work is to describe the epidemiology of systemic candidiasis in high-risk departments at the UHC and the ACC of BATNA. Patients and methods:
Ouanassa Hamouda, Allaoua Hichem Fendri
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Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes
eLife, 2020 The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity.
Peter C Dumoulin +4 more
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Nature Communications, 2022 1,2-Azoles are privileged structures in many natural products and drugs. The authors report an atroposelective synthesis of two types of axially chiral 1,2-azoles, through vinylidene ortho-quinone methide intermediates.
Yu Chang +6 more
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Frontiers in Cellular and Infection Microbiology, 2022 Scedosporium and Lomentospora infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi.
Zikuo Wang +5 more
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