Results 101 to 110 of about 34,737 (245)

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Predicting the Stability of Base‐mediated C─H Carboxylation Adducts Using Data Science Tools

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
A computational approach integrating quantum chemistry and machine learning enables the prediction of CO2–adduct stability. Model interpretability and experimental validation highlight its utility for designing base‐mediated C–H carboxylation reactions.
Maike Eckhoff, Shubham Deolka, Aleria Garcia‐Roca, Lilly Meynberg, Liudmila Seidel, Matthew S. Sigman, Jonny Proppe   +6 more
wiley   +2 more sources

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors

Frontiers in Microbiology, 2019
CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice.
Jingxiang Zhang, Liping Li, Liping Li, Quanzhen Lv, Lan Yan, Yan Wang, Yuanying Jiang, Yuanying Jiang, Yuanying Jiang   +8 more
doaj   +1 more source

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Stergiopoulos, I., Waard, M.A., De, Zwiers, L.H.   +3 more
core   +2 more sources

In Vitro Activities of Five Antifungal Drugs Against Conidia and Sclerotic Cells of Chromoblastomycosis Agent Fonsecaea spp

Microbiology and Immunology, EarlyView.
ABSTRACT Chromoblastomycosis (CBM) is a chronic skin and subcutaneous infection mainly caused by Fonsecaea pedrosoi, a dematiaceous fungus with various morphotypes. Characteristic sclerotic cells—globe‐shaped, multiseptated and pigmented—are found in lesions of infected individuals, though their differentiation in the host remains poorly understood. To
Aline Barral Takahashi, Daniella Paternostro de Araújo Grisólia, Moises Batista da Silva, Naila Ferreira da Cruz, Sâmela Miranda da Silva, Patrícia Fagundes da Costa, Claudio Guedes Salgado   +6 more
wiley   +1 more source

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in Candida Species

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta, Tal Kopp, Ivan Voronov, Adi Yona, Rania Hasib Afana, Shmuel Carmeli, Micha Fridman   +6 more
wiley   +2 more sources

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Venetoclax combined with cladribine, idarubicin, cytarabine (CLIA‐VEN) results in higher remission rates over conventional 7 + 3 chemotherapy without increased toxicity in newly diagnosed acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Induction chemotherapy in fit de novo acute myeloid leukaemia (AML) patients has historically combined an anthracycline with standard‐dose cytarabine (‘7 + 3’) despite complete response (CR) rates of 50%–70%. In May 2023, our institution adopted the utilization of cladribine, cytarabine, idarubicin and venetoclax (CLIA‐VEN) for intensive ...
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Anthony Quach, Yujiao Sun, Piyatida Chumnumsiriwath, Stefan O. Ciurea, Jorge Ramos‐Perez, Polina Bellman, Deepa Jeyakumar, Piyanuch Kongtim, Kiran Naqvi   +11 more
wiley   +1 more source

Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles

Clinical Case Reports, 2019
Key Clinical Message We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation.
Ikrame Chouchane, Nathalie Stremler‐Lebel, Philippe Reix   +2 more
doaj   +1 more source

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source