Results 101 to 110 of about 40,795 (299)

The effectiveness of voriconazole in therapy of Candida glabratas biofilms oral infections and its influence on the matrix composition and gene expression [PDF]

, 2017
Candida glabrata is one of most prevalente yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms.
Azeredo, Joana, Gonçalves, Bruna, Henriques, Mariana, Rodrigues, Célia F., Rodrigues, M. Elisa, Silva, Sónia Carina   +5 more
core   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation [PDF]

, 2008
Nitrogen heterocycles are present in many compounds of enormous practical importance, ranging from pharmaceutical agents and biological probes to electroactive materials.
Alberico D., Alonso F., Alvarez E., Bellina F., Bercaw J. E., Bergman R. G., Campeau L.-C., Canac Y., Chang L. L., Chatani N., Chen M. S., Chiong H. A., Cho J. -Y., Christ M. L., Clement N. D., Crabtree R. H., Daugulis O., Daugulis O., Diederich F., Do H.-Q., Dwyer C. L., Dyker G., Esteruelas M. A., Ferreira E. M., Gant T. G., Garcia-Cuadrado D., Graczyk P. P., Gribble M., Herrmann W. A., Hillier A. C., Hlasta D. J., Ishiyama T., Jia C. G., Johnson J. B., Kakiuchi F., Kakiuchi F., Kalyani D., Klingler R. J., Kreher R., Larhed M., Lewis J. C., Lewis J. C., Lewis J. C., Lewis J. C., Michael J. P., Miura M., Moore E. J., Netherton M. R., Peters M. W., Pivsa-Art S., Rech J. C., Ritleng V., Stuart D. R., Tan K. L., Tan K. L., Tan K. L., Tan K. L., Tan K. L., Tunge J. A., van Assema S. G. A., Wiedemann S. H., Wiedemann S. H., Wiedemann S. H., Yanagisawa S., Zharekeev B. K.   +64 more
core   +2 more sources

A Comparative Evaluation of Exoenzyme Production, Biofilm Development, and Cell Surface Hydrophobicity in Dominant Genotypes of Candida albicans

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of virulence trait assessment in Candida albicans clinical isolates. ABSTRACT Background Candida albicans exhibits significant genotypic diversity, and genotypes A and C are the most predominant clinical isolates. The aim of this study was to evaluate the virulence traits of these genotypes, focusing on exoenzyme production, biofilm ...
Hasti Nouraei, Neda Amirzadeh, Fatemeh Ahmadi, Keyvan Pakshir   +3 more
wiley   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

A Review of Antifungals and their Mono- and Combination- therapy in the Treatment of Invasive Fungal Infections [PDF]

Journal of Kerman University of Medical Sciences, 2016
Invasive fungal infections with high mortality rate are a growing health concern in hospitals and medical centers. The infection usually occurs in people with compromised immune systems.
Amir Arastefar, Parisa Badiee
doaj  

Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals

Journal of Infection in Developing Countries, 2009
Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited.
José Luis Arredondo-García, Carlos F. Amábile-Cuevas, RedMic2 Study Group   +2 more
doaj   +1 more source

Pharmacists' views on the implementation of therapeutic drug monitoring in oncology

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background There is increasing interest in the potential benefit of therapeutic drug monitoring (TDM) in oncology. However, uptake in Australian hospitals is limited. Aim This study sought to explore hospital pharmacists' experiences with TDM in oncology, seeking to determine if they could provide insights into barriers and facilitators to its
Jane E. Carland, Bridin Murnion, Thomas Sakellaris, Jana Stojanova   +3 more
wiley   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +2 more sources

Ueber die Wirkung der Chlormethylate einiger Azole auf Athmung und Kreislauf [PDF]

, 1896
H. Tappeiner
openalex   +1 more source