Results 11 to 20 of about 17,549 (193)

Azole Fungicides and Their Endocrine Disrupting Properties: Perspectives on Sex Hormone-Dependent Reproductive Development

Frontiers in Toxicology, 2022
Azoles are antifungal agents used in both agriculture and medicine. They typically target the CYP51 enzyme in fungi and, by so doing, disrupt cell membrane integrity. However, azoles can also target various CYP enzymes in mammals, including humans, which
Monica Kam Draskau, Terje Svingen
doaj   +1 more source

Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS

Thoracic Cancer, 2023
Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole ...
Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han   +9 more
doaj   +1 more source

Emergence and Genomic Characterization of Multidrug Resistant Candida auris in Nigeria, West Africa

Journal of Fungi, 2022
Candida auris is an emerging multidrug-resistant fungal pathogen that has become a worldwide public health threat due to the limitations of treatment options, difficulty in diagnosis, and its potential for clonal transmission.
Rita Oladele, Jessica N. Uwanibe, Idowu B. Olawoye, Abdul-Wahab O. Ettu, Jacques F. Meis, Christian T. Happi   +5 more
doaj   +1 more source

Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

Molecules, 2020
The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen, Prabhat Ranjan, Leonid G. Voskressensky, Erik V. Van der Eycken, Upendra K. Sharma   +4 more
doaj   +1 more source

Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

Journal of Fungi, 2022
A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections.
Dalibor Mijaljica, Fabrizio Spada, Ian P. Harrison   +2 more
doaj   +1 more source

Clinical Outcomes of Intra-Abdominal Candidiasis by Initial Antifungal Therapy. [PDF]

Mycoses
ABSTRACT Background Intra‐abdominal candidiasis (IAC) is a severe and heterogeneous infection associated with significant morbidity and mortality. Objectives To evaluate outcomes of IAC according to initial antifungal therapy and to identify predictors of persistent infection and 30‐day mortality.
Albanell-Fernández M, Vergara A, Marco F, Herrera S, Tuset M, Soriano A, Bodro M.   +6 more
europepmc   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Antifungal Resistance in Clinical Isolates of Candida glabrata in Ibero-America

Journal of Fungi, 2021
In different regions worldwide, there exists an intra-and inter-regional variability in the rates of resistance to antifungal agents in Candida glabrata, highlighting the importance of understanding the epidemiology and antifungal susceptibility profiles
Erick Martínez-Herrera, María Guadalupe Frías-De-León, Rigoberto Hernández-Castro, Eduardo García-Salazar, Roberto Arenas, Esther Ocharan-Hernández, Carmen Rodríguez-Cerdeira   +6 more
doaj   +1 more source

Study of Different Chiral Columns for the Enantiomeric Separation of Azoles Using Supercritical Fluid Chromatography

Separations, 2022
The enantiomeric separation of antifungal compounds is an arduous task in pharmaceutical and biomedical fields due to the different properties that each diastereoisomer presents.
Laura Toribio, Irene Magdaleno, Beatriz Martín-Gómez, María T. Martín, Silvia Valverde, Ana M. Ares   +5 more
doaj   +1 more source

Preparation and Utility of N-Alkynyl Azoles in Synthesis

Molecules, 2019
Heteroatom-substituted alkynes have attracted a significant amount of interest in the synthetic community due to the polarized nature of these alkynes and their utility in a wide range of reactions.
Brandon Reinus, Sean M. Kerwin
doaj   +1 more source