Results 11 to 20 of about 22,992 (261)
Nature Communications, 2022 1,2-Azoles are privileged structures in many natural products and drugs. The authors report an atroposelective synthesis of two types of axially chiral 1,2-azoles, through vinylidene ortho-quinone methide intermediates.
Yu Chang +6 more
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Frustration on a centred pyrochlore lattice in metal-organic frameworks [PDF]
Phys. Rev. Research 5, L022018 (2023), 2022 Geometric frustration inhibits magnetic systems from ordering, opening a window to unconventional phases of matter. The paradigmatic frustrated lattice in three dimensions to host a spin liquid is the pyrochlore, although there remain few experimental compounds thought to realize such a state.
arxiv +1 more source
Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes
eLife, 2020 The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity.
Peter C Dumoulin +4 more
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Frontiers in Toxicology, 2022 Azoles are antifungal agents used in both agriculture and medicine. They typically target the CYP51 enzyme in fungi and, by so doing, disrupt cell membrane integrity. However, azoles can also target various CYP enzymes in mammals, including humans, which
Monica Kam Draskau, Terje Svingen
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Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives [PDF]
Trends in Pharmaceutical Sciences, 2022 In recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value.
Sara Sadeghian +6 more
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Thoracic Cancer, 2023 Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole ...
Mengming Xia +9 more
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Molecules, 2020 The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen +4 more
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Farmacología de los azoles [PDF]
Revista Iberoamericana de Micología, 2007 Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake. All of them have high tissue distribution with low plasma concentrations, especially low in the case of ...
Garcia-Quetglas, E. (Emilio) +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 BackgroundCryptococcosis is a global invasive mycosis with high rates of morbidity and mortality, especially in AIDS patients. Its treatment remains challenging because of the limited antifungals and their unavoidable toxicity, and as such more efforts ...
Yali Li +4 more
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Preparation and Utility of N-Alkynyl Azoles in Synthesis
Molecules, 2019 Heteroatom-substituted alkynes have attracted a significant amount of interest in the synthetic community due to the polarized nature of these alkynes and their utility in a wide range of reactions.
Brandon Reinus, Sean M. Kerwin
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