Results 21 to 30 of about 22,992 (261)
Bioorganic & Medicinal Chemistry Letters, 2010 The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Minaho Shirakura +6 more
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Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles
Beilstein Journal of Organic Chemistry, 2021 Desulfonylative alkylation of N-tosyl-1,2,3-triazoles under metal-free conditions leading to β-triazolylenones is reported here. The present study encompasses the synthesis of triazoles with a new substitution pattern in a single step from cyclic 1,3 ...
Soumyaranjan Pati +3 more
doaj +1 more source
European Journal of Clinical Microbiology & Infectious Diseases, 1997 Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
G. G. Baily +3 more
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Nature Communications, 2020 Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient ...
Ferdinand H. Lutter +6 more
doaj +1 more source
Azole potentiation in Candida species
PLOS Pathogens, 2023 Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence.
Jan S. Stenkiewicz-Witeska +1 more
openaire +4 more sources
Nuclear Quadrupole Resonance Spectroscopy: Tautomerism and Structure of Functional Azoles
Crystals, 2019 The Nuclear Quadrupole Resonance spectroscopy data of functionalized azoles (imidazoles, triazoles and corresponding benzazoles) are reviewed and critically discussed. The possibility of studying the tautomerism of azoles by the NQR method is considered.
Lyudmila I. Larina
doaj +1 more source
LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles
Frontiers in Microbiology, 2020 Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs.
Svyatoslav S. Sokolov +11 more
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Trichosporon asahii Infective Endocarditis of Prosthetic Valve: A Case Report and Literature Review
Antibiotics, 2023 Trichosporon spp. endocarditis is a severe and hard-to-treat infection. Immunosuppressed subjects and carriers of prosthetic valves or intracardiac devices are at risk.
Alice Mulè +13 more
doaj +1 more source
Understanding corrosion inhibition with van der Waals DFT methods: the case of benzotriazole [PDF]
Faraday Discuss. (2015) 180, 439-458, 2015 The corrosion of materials is an undesirable and costly process affecting many areas of technology and everyday life. As such, considerable effort has gone into understanding and preventing it. Organic molecule based coatings can in certain circumstances act as effective corrosion inhibitors.
arxiv +1 more source
Liquid Coordination Polymers with Anhydrous Proton Conductivity
Angewandte Chemie, EarlyView.Functional liquid coordination polymers near ambient conditions are prepared by introducing H3PO4 as a network modifier. This process disrupts extended coordination networks, producing a stable liquid. Liquid properties are controlled by tuning the ratio of network modifiers, resulting in anhydrous proton conductivity up to 27 mS cm−1 at 353 K and ...
Nattapol Ma +3 more
wiley +2 more sources