Results 41 to 50 of about 34,737 (245)

Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]

, 2020
The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F, Karmel, Caleb, Kharitonova, Elena V, Rubel, Camille Z   +3 more
core   +1 more source

Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates. [PDF]

, 2012
The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of
Ahrendt, Albery, Almaşi, Baidya, Brazier, Brotzel, Diner, Dominguez de Maria, Enders, Erkkilä, Grošelj, Herbert Mayr, Komisarska, Lakhdar, Lakhdar, Lelais, List, List, MacMillan, Mahiuddin Baidya, Marcus, Mayr, Mayr, Mayr, Mayr, Mayr, Sami Lakhdar, Schmid, Schmid, Schmid, Seayad, Seebach, Tsogoeva, Uria   +33 more
core   +1 more source

Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides

Frontiers in Microbiology, 2013
Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa ...
Xianyun eSun, Wenzhao eWang, Kangji eWang, Xinxu eYu, Jie eLiu, Fucai eZhou, Baogui eXie, Shaojie eLi   +7 more
doaj   +1 more source

LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles

Frontiers in Microbiology, 2020
Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs.
Svyatoslav S. Sokolov, Margarita A. Vorobeva, Alexandra I. Smirnova, Alexandra I. Smirnova, Ekaterina A. Smirnova, Nataliya I. Trushina, Nataliya I. Trushina, Kseniia V. Galkina, Kseniia V. Galkina, Fedor F. Severin, Dmitry A. Knorre, Dmitry A. Knorre   +11 more
doaj   +1 more source

Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans

Antibiotics
Background/Objectives: The diminished efficacy of azoles in treating fungal infections is attributed to the emergence of resistance among pathogenic fungi. Employing a synergistic approach with other compounds to enhance the antifungal activity of azoles
Sijin Hang, Li Wang, Zhe Ji, Xuqing Shen, Xinyu Fang, Wanqian Li, Yuanying Jiang, Hui Lu   +7 more
doaj   +1 more source

Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]

, 2014
Peer reviewedPublisher ...
Broenen, Emmi, Brüggemann, Roger, Kamphuis-van Ulzen, Karin, Mavinkurve-Groothuis, Annelies, Verweij, Paul, Warris, Adilia   +5 more
core   +2 more sources

Azoles

, 2014
Capítulo cuarto del temario del segundo bloque de la asignatura Ampliación de Química Orgánica Avanzada. Azoles.
Raoul Herbrecht, Yasmine Nivoix
openaire   +3 more sources

Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection [PDF]

, 2019
Background: In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL).
Acosta-Serrano, Álvaro, Al-Salem, Waleed S., Al-Shahrani, Ali M., Alraey, Yasser, Alsohibany, Khalid S., Alyamani, Essam J., Alzahrani, Mohamed H., Alzeyadi, Zeyad, Assiri, Abdullah M., Balghonaim, Salah M., Casas-Sánchez, Aitor, Dyer, Naomi A., Halliday, Alice, Kelly-Hope, Louise, Memish, Ziad, Solórzano, Carla, Weedall, Gareth D.   +16 more
core   +9 more sources

Azole resistance inCandida

European Journal of Clinical Microbiology & Infectious Diseases, 1997
Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W., Baily, G.G., Hood, S.V.
openaire   +4 more sources

In vitro biofilms and antifungal susceptibility of dermatophyte and non-dermatophyte moulds involved in foot mycosis [PDF]

, 2017
Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms.
Bougnoux, Marie Élisabeth, Corpologno, Serena, El Euch, Dalenda, Sadfi-Zouaoui, Najla, Simonetti, Giovanna, Toukabri, Nourchéne   +5 more
core   +1 more source