Results 51 to 60 of about 22,992 (261)

Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles

open access: yesClinical Case Reports, 2019
Key Clinical Message We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation.
Ikrame Chouchane   +2 more
doaj   +1 more source

Intravenous posaconazole: key features of clinical pharmacology and practical applications

open access: yesОнкогематология, 2022
Invasive fungal infections in various categories of patients remain one of the most urgent problems of modern medicine. This is complicated by the imperfection of diagnostic methods, as well as a small range of antimycotics for systemic use.
A. V. Veselov, N. N. Klimko
doaj   +1 more source

Covalent Organic Frameworks for Photocatalysis

open access: yesAdvanced Materials, EarlyView.
This review provides an overview of recent advances in covalent organic frameworks (COFs) for photocatalysis, focusing on sustainable energy applications like water splitting, hydrogen peroxide generation, and CO2 and N2 reduction. It discusses design principles, structure‐function relationships, challenges in COF photocatalysis, and strategies to ...
Bikash Mishra   +6 more
wiley   +1 more source

Linezolid in Combination With Azoles Induced Synergistic Effects Against Candida albicans and Protected Galleria mellonella Against Experimental Candidiasis

open access: yesFrontiers in Microbiology, 2019
The incidence of resistant Candida isolates has increased continuously in recent decades, especially Candida albicans. To overcome this resistance, research on antifungal sensitizers has attracted considerable attention.
Mengjiao Lu   +7 more
doaj   +1 more source

In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

open access: yesMolecules, 2013
Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole.
Maha S. Almutairi   +3 more
doaj   +1 more source

Ruthenium‐Katalysierte ortho‐Arylierung von Benzoesäuren mit Arylthianthreniumsalzen

open access: yesAngewandte Chemie, EarlyView.
Es wurde eine katalytische Ortho‐Arylierungsmethode entwickelt, mit der Arylthianthreniumsalze in Carboxylat‐funktionalisierte Biaryle umgewandelt werden können. Die Carboxylatgruppe kann in situ entfernt oder für eine weitere Derivatisierung verwendet werden.
Kaiping Wang   +9 more
wiley   +1 more source

Interfacial Photoelectrochemistry in Organic Synthesis

open access: yesAngewandte Chemie International Edition, Accepted Article.
Photoelectrodes have traditionally enjoyed widespread attention as heterogeneous catalysts for the activation of water and CO2 in energy research, while photoelectrochemistry with homogeneous molecular catalysts dominates the activations of more complex molecules in organic synthesis.
Gabriel Chan   +4 more
wiley   +1 more source

History of the development of azole derivatives [PDF]

open access: yesClinical Microbiology and Infection, 2004
Until the 1940s, relatively few agents were available for the treatment of systemic fungal infections. The development of the polyene antifungals represented a major advance in medical mycology. Although amphotericin B quickly became the mainstay of therapy for serious infections, its use was associated with infusion-related side-effects and dose ...
openaire   +3 more sources

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors

open access: yesFrontiers in Microbiology, 2019
CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice.
Jingxiang Zhang   +8 more
doaj   +1 more source

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