Results 81 to 90 of about 34,737 (245)

A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture. [PDF]

, 2017
We evaluated the effect of six azoles on embryonic development in the rat whole embryo culture (WEC). Using the total morphological scoring system (TMS), we calculated the ID10concentration (effective dose for 10% decrease in TMS).
Dimopoulou, Myrto, Pennings, Jeroen L A, Piersma, Aldert H, Rietjens, Ivonne M C M, van Ravenzwaay, Bennard, Verhoef, Aart   +5 more
core   +3 more sources

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

An integrated social and natural sciences case study for the reuse of organic wastes as soil amendments

PLANTS, PEOPLE, PLANET, EarlyView.
Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder, Jose‐Luis Fajardo‐Escoffié, Laura Carter, Emily K. Durant, Katie J. Field, John Nightingale, Brett Sallach, Andrea‐Lorena Garduño‐Jiménez   +7 more
wiley   +1 more source

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

PLANTS, PEOPLE, PLANET, EarlyView.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter, Evyatar Ben Mordechay, Benny Chefetz, Zeyou Chen, Xinyi Cui, Jay Gan, Hui Li, Audrey Moores, Xiaoyu Gao   +8 more
wiley   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +2 more sources

Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole

Bioorganic & Medicinal Chemistry Letters, 2010
The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Yasushi, Todoroki, Kumi, Naiki, Hikaru, Aoyama, Minaho, Shirakura, Kotomi, Ueno, Masaharu, Mizutani, Nobuhiro, Hirai   +6 more
openaire   +2 more sources

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source

Azole-ResistantAspergillus fumigatus, Iran

Emerging Infectious Diseases, 2013
To the Editor: Aspergillus fumigatus causes a variety of diseases in humans. The drugs recommended for treatment of Aspergillus diseases are the mold-active azole antifungal drugs (1). However, a wide range of mutations in A. fumigatus confer azole resistance, which commonly involves modifications in the cyp51A gene (2), the target for azole antifungal
Seyedmousavi, S., Hashemi, S.J., Zibafar, E., Zoll, J., Hedayati, M.T., Mouton, J.W., Melchers, W.J.G., Verweij, P.E.   +7 more
openaire   +5 more sources

A new method to measure EC50 reveals cultivar‐specific fungicide resistance and very high diversity within experimental field populations of Zymoseptoria tritici

Pest Management Science, EarlyView.
We isolated Zymoseptoria tritici strains from a diverse wheat field and quantified fungicide resistance using a novel plate assay. We found high diversity in fungicide sensitivity and host–fungicide–pathogen interactions. Abstract BACKGROUND Zymoseptoria tritici causes Septoria tritici blotch (STB), the most damaging wheat disease in Europe. In Europe,
Firas Talas, Jessica Stapley, Bruce A McDonald   +2 more
wiley   +1 more source

The effectiveness of voriconazole in therapy of Candida glabratas biofilms oral infections and its influence on the matrix composition and gene expression [PDF]

, 2017
Candida glabrata is one of most prevalente yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms.
Azeredo, Joana, Gonçalves, Bruna, Henriques, Mariana, Rodrigues, Célia F., Rodrigues, M. Elisa, Silva, Sónia Carina   +5 more
core   +1 more source