Results 31 to 40 of about 25,799 (236)

Catalyst-Free [3+2] Cycloaddition of Electron-Deficient Alkynes and o‑Hydroxyaryl Azomethine Ylides in Water [PDF]

ACS Omega, 2020
Jin Zhu, Wenbo Su, Cheng Xiong, Ruifang Bai, Qingfa Zhou, Ming Chen   +5 more
doaj   +2 more sources

Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors. [PDF]

ChemMedChem, 2019
Gollner A, Weinstabl H, Fuchs JE, Rudolph D, Garavel G, Hofbauer KS, Karolyi-Oezguer J, Gmaschitz G, Hela W, Kerres N, Grondal E, Werni P, Ramharter J, Broeker J, McConnell DB.   +14 more
europepmc   +3 more sources

Recent Advances in the Catalytic Enantioselective [3+2] Cycloaddition of N-Metalated Azomethine Ylides.

Chemistry, 2023
Asymmetric [3+2] cycloaddition reactions are fascinating and powerful methods for the synthesis of enantioenriched pyrrolidines up to four stereocentres. Pyrrolidines are important compounds for both biology and organocatalytic applications.
S. Kumar, P. Guiry
semanticscholar   +1 more source

Substituted proline derivatives as organocatalysts in Michael reaction [PDF]

Journal of the Serbian Chemical Society, 2014
Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, have been studied as organocatalysts in Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10
Jovanović Predrag, Ranđelović Jelena, Ivković Branka, Suteu Cristina, Tokić-Vujosević Zorana, Savić Vladimir   +5 more
doaj   +1 more source

Synthesis of Spirocyclic Amines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Azomethine Imines [PDF]

Synthesis, 2020
Simple ketone starting materials with a halide leaving group and an alkene were prepared in one step and heated with glycine or glycine esters to promote a tandem imine formation, cyclization, and dipolar cycloaddition cascade. The chemistry was also feasible with acetylhydrazide.
Choi, A., Castle, J., Saruengkhanphasit, R., Coldham, I.   +3 more
openaire   +2 more sources

Intramolecular Cycloaddition of Imines of Cysteine Derivatives

Molecules, 1998
Azomethine ylides were generated from Schiffs bases of S-allylcysteine methyl ester and their intramolecular 1,3-dipolar cycloadditions were studied. These reactions led to the synthesis of thieno[3,4-b]pyrrole derivatives in good yield.
Teresa M. V. D. Pinho e Melo, António M. d'A Rocha Gonsalves, Ana M. T. D. P. V. Cabral   +2 more
doaj   +1 more source

Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2‐Bis(Diazo)Alkanes to 1,2,3,4‐Tetrazines and Subsequent Fragmentations

Angewandte Chemie, EarlyView.
DFT calculations of the 8π‐electrocyclization of 1,2‐bis(diazo)alkanes and of other bis‐1,3‐dipoles reveal that this process can establish a so far ignored route to heterocycles such as 1,2,3,4‐tetrazines. Alternative reaction channels via carbenes or nitrenes leading to fragmentation products are discussed.
Hans‐Ulrich Reissig, Ernst‐Ulrich Würthwein   +1 more
wiley   +2 more sources

Synthesis and Application of Bioactive N‐Functionalized Aziridines

Angewandte Chemie, EarlyView.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan, Samya Samanta, Nan Qiu, Alexander Adibekian, David C. Powers   +4 more
wiley   +2 more sources

Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts

Beilstein Journal of Organic Chemistry, 2019
Quinolinium salts, Q+-CH2-CO2Me Br− and Q+-CH2-CONMe2 Br− (where Q = quinoline), were prepared from quinolines. Deprotonation of these salts with triethylamine promoted the reaction of the resulting quinolinium ylides (formally azomethine ylides) with ...
Anthony Choi, Rebecca M. Morley, Iain Coldham   +2 more
doaj   +1 more source

Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

Molecules, 2014
Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields.
Jairo Quiroga, Jaime Gálvez, Rodrigo Abonia, Braulio Insuasty, Alejandro Ortíz, Justo Cobo, Manuel Nogueras   +6 more
doaj   +1 more source