Results 71 to 80 of about 15,583 (213)

Discovery of cancer-preventive juices reactivating RB functions

Environmental Health and Preventive Medicine, 2023
Background: Recent advances have been achieved in the genetic diagnosis and therapies against malignancies due to a better understanding of the molecular mechanisms underlying carcinogenesis.
Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai   +7 more
doaj   +1 more source

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins [PDF]

, 2008
O[superscript 6]-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal
Bugni, J. M., Meira, Lisiane B., Samson, Leona D.   +2 more
core   +1 more source

Health Effects of Bee Products: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Nutritional composition of bee products and some health effects. ABSTRACT Honey, bee pollen, propolis, bee bread, royal jelly, bee venom, beeswax, and apilarnil are among the bee‐derived products that may serve health‐related purposes, as they exhibit various biological activities such as antibacterial, antiviral, antifungal, antioxidant, anti ...
Nevin Sanlier, Elif Yildiz Kaya, Ikbal Irem Yucel   +2 more
wiley   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang, Yiming Liam Liu, Yidi Augenstern Du, Shan−Shan Wang, Bo O. Zhou   +4 more
wiley   +1 more source

Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats [PDF]

International Journal of Molecular Sciences, 2013
Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats.
Kochi, Takahiro, Shimizu, Masahito, Ohno, Tomohiko, Baba, Atsushi, Sumi, Takafumi, Kubota, Masaya, Shirakami, Yohei, Tsurumi, Hisashi, Tanaka, Takuji, Moriwaki, Hisataka   +9 more
openaire   +2 more sources

Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]

, 1997
The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E., Jacquinet, Claire, Peiffer, Ginette, Taché, Sylviane   +3 more
core   +1 more source

Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR‐29a‐5p/P53 Signaling in the Tumor Microenvironment

Molecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.
Tianma granule (TMG) inhibits colorectal cancer progression by modulating miR‐29a‐5p/P53 signaling in the tumor microenvironment, reducing stromal senescence and countering pro‐tumorigenic effects. ABSTRACT Chemotherapy‐induced senescence‐associated tumor microenvironment (S‐TME) facilitates colorectal cancer (CRC) progression.
Xiaojuan Tang, Yuan Ren, Yongmin Li, Yuan Lv, Liang Zhao, Yongheng He   +5 more
wiley   +1 more source

Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol

Biology
Hepatic encephalopathy (HE) is a neurological condition linked to liver failure. Acute HE (Type A) occurs with acute liver failure, while chronic HE (Type C) is tied to cirrhosis and portal hypertension. HE treatments lag due to gaps in understanding its
Xiao Y. Tong, Hussain Hussain, Nagarajarao Shamaladevi, Michael D. Norenberg, Aya Fadel, Omar El Hiba, El got Abdeljalil, Bilal El-Mansoury, Deepak Kempuraj, Sampath Natarajan, Andrew V. Schally, Miklos Jaszberenyi, Luis Salgueiro, Michael J. Paidas, Arumugam R. Jayakumar   +14 more
doaj   +1 more source

Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. [PDF]

PLoS ONE, 2013
Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development.
Iina Tuominen, Leina Al-Rabadi, Dimitris Stavrakis, Iordanis Karagiannides, Charalabos Pothoulakis, James M Bugni   +5 more
doaj   +1 more source