Results 1 to 10 of about 20,077 (158)

Comparative analysis of the effects of aztreonam combined with four β-lactamase inhibitors against carbapenem-resistant <i>Enterobacterales</i>. [PDF]

Microbiol Spectr
Carbapenem-resistant Enterobacterales (CRE) pose a global public health threat due to multidrug resistance and treatment failure. This study evaluated the effects of aztreonam combined with four β-lactamase inhibitors (avibactam, clavulanic acid ...
Meng Q, Xu C, Li W, Shen K, Huang X, Fu X, Zhou L, Chen Y, Hu F, Wang H.   +9 more
europepmc   +2 more sources

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Antibiotics, 2021
Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%).
Alberto Enrico Maraolo, Stefano Di Bella, Francesco Luzzaro   +2 more
exaly   +3 more sources

High <i>in vitro</i> activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in <i>Escherichia coli</i> in the United States Mid-Atlantic region. [PDF]

Microbiol Spectr
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eklund E, Maruca T, Kruczynski K, Critchfield H, Murphy R, Keller E, Lee B, Patel A, Klein L, Torpey DA, Myers RA, Campodónico VL.   +11 more
europepmc   +2 more sources

In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria

Antibiotics, 2023
Background: Despite the availability of new options (ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam and cefiderocol), it is still very difficult to treat infections caused by metallo-β-lactamase (MBLs)-producers resistant to aztreonam.
Cécile Emeraud, Sandrine Bernabeu, Laurent Dortet   +2 more
doaj   +1 more source

Experimental Design Supported Liposomal Aztreonam Delivery: In Vitro Studies [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: The present study focuses on a systemic approach to develop liposomal aztreonam as a promising dosage form for inhalation therapy in the treatment of pneumonia and explores the in-vitro antimicrobial and cell uptake efficacy.
Sayani Bhattacharyya, Preethi Sudheer, Kuntal Das, Subhabrata Ray   +3 more
doaj   +1 more source

Insight into the Interaction Mechanism of HSA with Aztreonam: A Multispectroscopic and Computational Approach

Molecules, 2022
Aztreonam is a Gram-negative bacteria-targeting synthetic monobactam antibiotic. Human serum albumin (HSA) plays an important role in the transference of pharmaceuticals, hormones, and fatty acids, along with other compounds, determining their ...
Amal A. Sabour, Altaf Khan, Mohammed R. Alhuzani   +2 more
doaj   +1 more source

In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes

Microbiology Spectrum, 2021
Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates.
David R. Snydman, Laura McDermott
doaj   +1 more source

Aztreonam Lysine Increases the Activity of Phages E79 and phiKZ against Pseudomonas aeruginosa PA01

Microorganisms, 2021
Pseudomonas aeruginosa is a pernicious bacterial pathogen that is difficult to treat because of high levels of antibiotic resistance. A promising alternative treatment option for such bacteria is the application of bacteriophages; the correct combination
Carly M. Davis, Jaclyn G. McCutcheon, Jonathan J. Dennis   +2 more
doaj   +1 more source

Recent Trends in Prostate Biopsy Complication Rates and the Role of Aztreonam in Periprocedural Antimicrobial Prophylaxis—A Nationwide Population-Based Study from Korea

Antibiotics, 2022
An increase in the rate of complications after prostate biopsy (PB) due to increased antibiotic-resistant bacteria is a global issue. We report the safety of aztreonam as a prophylactic antibiotic in patients undergoing PB.
Wook Nam, Min Uk Park, Han Kyu Chae, Jihye Song, Han Gwun Kim, Jong Yeon Park, Seokjoon Lee, Sung Jin Kim   +7 more
doaj   +1 more source

Genomic New Insights Into Emergence and Clinical Therapy of Multidrug-Resistant Klebsiella pneumoniae in Infected Pancreatic Necrosis

Frontiers in Microbiology, 2021
Infected pancreatic necrosis (IPN) is a key risk factor in the progression of severe acute pancreatitis, and use of antibiotics is one of the main clinical actions.
Haibin Hao, Yang Liu, Jin Cao, Kun Gao, Kun Gao, Yingying Lu, Yingying Lu, Weiping Wang, Peng Wang, Sida Lu, Long Hu, Zhihui Tong, Weiqin Li, Weiqin Li, Weiqin Li   +14 more
doaj   +1 more source