Results 31 to 40 of about 20,077 (158)

A Study on Ceftazidime/Avibactam and Aztreonam Synergy Among Aztreonam-resistant Metallo-β-lactamase Producing Enterobacterales in a Tertiary Care Hospital

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Global detection of bacteria harboring metallo-β-lactamase (MBL) genes has increased at an alarming rate. However, there is no concurrent increase in available antibiotics for treatment, which has turned these infections into a public ...
Adelyn D’SOUZA, Rachana SHETTY, Asha Pai KB   +2 more
doaj   +1 more source

Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales [Corrigendum]

Infection and Drug Resistance, 2021
Tan X, Kim HS, Baugh K, et al. Infect Drug Resist.2021;14:125–142.  Page 134, left column, second paragraph, fourth sentence from the bottom, the text “Generally, all four tetracyclines have higher tissue concentrations than ...
Tan X, Kim HS, Baugh K, Huang Y, Kadiyala N, Wences M, Singh N, Wenzler E, Bulman ZP   +8 more
doaj  

In vitro activity of aztreonam in combination with relebactam against gram-negative pathogens producing various serine and metallo-β-lactamases

Journal of Global Antimicrobial Resistance
Objectives: Infections caused by carbapenemase-producing Gram-negative pathogens have become a significant global public health challenge due to limited treatment options.
Kengo Hayashi, Masahiro Suzuki, Yoshikazu Ishii, Yasufumi Matsumura, Kazuaki Matsumoto, Sho Saito, Yohei Doi   +6 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America

Microbiology Spectrum, 2022
Reports of Gram-negative bacteria harboring multiple carbapenemase genes have increased in South America, leading to an urgent need for appropriate microbiological diagnosis.
Felipe Vásquez-Ponce, Karine Dantas, Johana Becerra, Gregory Melocco, Fernanda Esposito, Brenda Cardoso, Larissa Rodrigues, Keila Lima, Aline V. de Lima, Fábio P. Sellera, Renata Mattos, Lucas Trevisoli, Marco A. Vianello, Thais Sincero, Jose Di Conza, Eliana Vespero, Gabriel Gutkind, Jorge Sampaio, Nilton Lincopan   +18 more
doaj   +1 more source

Decision fatigue in hospital medicine: A retrospective exploratory evaluation

Journal of Hospital Medicine, EarlyView.
Abstract Background “Decision fatigue” (DF) is the deterioration in decision‐making ability stemming from repeated decision making. Objective Explore DF over the clinical workblock and across hospitalist and work characteristics. Methods Patients seen by hospitalists at two hospitals in January and February 2022 were retrospectively evaluated for ...
Rachel M. Kruer, LaKeisha Boyd, Lauren Czosnowski, Sarah Jones, Kelsey Perry, Thomas J. Streepey, Areeba Kara   +6 more
wiley   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli

Molecular Microbiology, EarlyView.
SanA is a novel regulator of peptidoglycan synthesis, potentially through functional interplay with PBP1B‐dependent pathways. ABSTRACT Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by
Honoka Yamaguchi, Risa Ago, Yuhei O. Tahara, Mari Inoue, Hironori Niki, Makoto Miyata, Daisuke Shiomi   +6 more
wiley   +1 more source

Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli

Frontiers in Microbiology, 2022
Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be ...
Ke Ma, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +3 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source