Cells, 2021 Prediction of linear B cell epitopes is of interest for the production of antigen-specific antibodies and the design of peptide-based vaccines. Here, we present BCEPS, a web server for predicting linear B cell epitopes tailored to select epitopes that ...
Alvaro Ras-Carmona +3 more
doaj +2 more sources
B-cell epitopes: Discontinuity and conformational analysis [PDF]
Molecular Immunology, 2019 Peptide vaccines have many potential advantages over conventional ones including low cost, lack of need for cold-chain storage, safety and specificity. However, it is well known that approximately 90% of B-cell epitopes (BCEs) are discontinuous in nature making it difficult to mimic them for creating vaccines. In this study, the degree of discontinuity
Saba, Ferdous +4 more
core +5 more sources
Computational perspectives revealed prospective vaccine candidates from five structural proteins of novel SARS corona virus 2019 (SARS-CoV-2) [PDF]
PeerJ, 2020 Background The present pandemic COVID-19 is caused by SARS-CoV-2, a single-stranded positive-sense RNA virus from the Coronaviridae family. Due to a lack of antiviral drugs, vaccines against the virus are urgently required.
Rajesh Anand +3 more
doaj +2 more sources
Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR [PDF]
, 2004 Organisms in the genus Anaplasma express an immunodominant major surface protein 2 (MSP2), composed of a central hypervariable region (HVR) flanked by highly conserved regions.
Abbott, Jeffrey R +6 more
core +1 more source
Identification of B-cell epitopes of Indian Zika virus strains using immunoinformatics [PDF]
Frontiers in ImmunologyGajanan Sapkal +2 more
exaly +2 more sources
Clinical and Experimental Immunology, 2000 SUMMARYA phage displayed dodecapeptide library and synthetic octapeptides spanning the complete sequence of α- and γ-type gliadin and overlapping in six amino acids (pepscan) were screened for binding to human gliadin antibodies (AGA). Phage display experiments led to four sequences recognized with significantly higher frequency by sera with raised IgA-
A A, Osman +7 more
openaire +3 more sources
HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis. [PDF]
, 2001 Few target epitopes have been described for human CD8 T lymphocytes in antigens of Mycobacterium tuberculosis. By use of a reverse immunogenetics approach, 23 motif-bearing peptides of the Ag85 complex were tested for binding to HLA-B*35, one of the ...
Ogg, GS +8 more
core +1 more source
Computational characterization of B-cell epitopes [PDF]
Molecular Immunology, 2008 Characterizing B-cell epitopes is a fundamental step for understanding the immunological basis of bio-recognition. To date, epitope analyses have either been based on limited structural data, or sequence data alone. In this study, our null hypothesis was that the surface of the antigen is homogeneously antigenic.
Nimrod D, Rubinstein +5 more
openaire +2 more sources
T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects [PDF]
, 2009 Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Tordesillas Villuendas, Leticia +17 more
core +1 more source
Clinical & Translational Immunology, 2020 Objectives Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and as a non‐specific immunisation method against the virus.
Szabolcs Urbán +4 more
doaj +1 more source