Results 291 to 300 of about 773,820 (334)

Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506 [PDF]

, 1991
Abu-Elmagd, K, Alessiani, M, Bryant, J, Fung, J, Herberman, RB, Jain, A, Starzl, TE, Whiteside, TL, Wilson, J, Zeevi, A   +9 more
core  

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes. [PDF]

Drug Des Devel Ther
Li JJ, Li L, Li S, Tang XY, Sun HF, Liu JX.   +5 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes. [PDF]

Mol Cancer Ther
Sur S, Bhartiya P, Steele R, Brennan M, DiPaolo RJ, Ray RB.   +5 more
europepmc   +1 more source

Exploring the causal relationship between B lymphocytes and Parkinson's disease: a bidirectional, two-sample Mendelian randomization study. [PDF]

Sci Rep
Song J, Qin Y, Wang L, Quan W, Xu J, Li J, Chen J.   +6 more
europepmc   +1 more source

Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain. [PDF]

Br J Anaesth
Parisien M, van Reij RRI, Khoury S, Koseli E, Karaky M, Silva JR, Taheri G, van den Hoogen NJ, Peng G, Allegri M, De Gregori M, Chelly JE, Rakel BA, Aasvang EK, Kehlet H, Buhre WFFA, Bryant CD, Damaj MI, King IL, Ghasemlou N, Mogil JS, Joosten EAJ, Diatchenko L.   +22 more
europepmc   +1 more source

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B-lymphocyte subpopulations

Immunology Today, 1983
B lymphocytes are exceptionally diverse, partly because different clones have membrane receptors with specificities for different antigens and partly because the cells exist in a series of distinct differentiation states and may constitute more than a single cellular lineage.
J T, Kung, W E, Paul
openaire   +2 more sources

Suppressor B lymphocytes

Immunology Today, 1983
B cells can influence an immune response in an antigen-specific manner by generating antibody which shuts down the response through negativefeedback. But there is growing evidence that B cells can also act upon antibody production as non-specific suppressor cells.
K M, Gilbert, M K, Hoffmann
openaire   +2 more sources