Optimized cumate toolkit for tunable protein expression during in vitro and in vivo studies of Burkholderia cenocepacia [PDF]
Applied and Environmental MicrobiologyInducible gene expression is pivotal to dissect bacterial physiology and virulence mechanisms. Across the Burkholderia genus, a limited range of inducible systems currently exist that allow tight regulation.
Hamza Tahir +3 more
doaj +2 more sources
Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein [PDF]
PLoS ONE, 2013 Cystic fibrosis (CF) is the most common lethal inherited genetic disorder affection Caucasians. Even with medical advances, CF is life-shortening with patients typically surviving only to age 38.
Lauren O Bakaletz +2 more
exaly +2 more sources
Catheter-Associated Burkholderia cenocepacia Infective Endocarditis in a Patient Receiving Maintenance Hemodialysis [PDF]
Case Reports in Infectious DiseasesBurkholderia cenocepacia, a member of the Burkholderia cepacia complex (BCC), is an opportunistic, intrinsically multidrug-resistant Gram-negative bacillus most commonly associated with nosocomial outbreaks and chronic pulmonary infection in patients ...
Zhong Xhen Khor +3 more
doaj +2 more sources
Deciphering the Role of RND Efflux Transporters in Burkholderia cenocepacia [PDF]
PLoS ONE, 2011 Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically ...
Elena Perrin +2 more
exaly +2 more sources
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]
PLoS ONE, 2017 Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Gilles Brackman +2 more
exaly +2 more sources
Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition. [PDF]
ChembiochemThe molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Zineddu S +7 more
europepmc +2 more sources
Characterization of the Burkholderia cenocepacia TonB Mutant as a Potential Live Attenuated Vaccine
Vaccines, 2017 Burkholderia cenocepacia is an opportunistic pathogen prevalent in cystic fibrosis patients, which is particularly difficult to treat, causing chronic and eventually fatal infections.
Alfredo G Torres, Julia N. Myers
exaly +3 more sources
Response of Burkholderia cenocepacia H111 to Micro-Oxia [PDF]
PLoS ONE, 2013 B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis (CF). In the CF lung bacteria grow to high densities within the viscous mucus that is limited in oxygen. Pseudomonas aeruginosa,
Leo Eberl +2 more
exaly +2 more sources
Microbiology Spectrum, 2023 Burkholderia cenocepacia is an opportunistic pathogen correlated with increased disease severity and mortality in cystic fibrosis (CF) patients.
Yossef Av-Gay +2 more
exaly +3 more sources
Phylogeny, Synteny, and Distribution of Type III Secretion Systems in Burkholderia cenocepacia: A Closer Look Into Host Span [PDF]
MicrobiologyOpenType III secretion systems (T3SS) have been described in many Gram‐negative bacteria, including the human opportunistic pathogen Burkholderia cenocepacia, originally described in association with plants. The present work aimed to identify T3SS genes in a
Gabrielle Tomé Cordeiro +5 more
doaj +2 more sources