Transcriptional responses of
BMC Genomics, 2011 Background Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in ...
Molinaro Antonio +4 more
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Response of Burkholderia cenocepacia H111 to Micro-Oxia [PDF]
PLoS ONE, 2013 B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis (CF). In the CF lung bacteria grow to high densities within the viscous mucus that is limited in oxygen. Pseudomonas aeruginosa,
Gabriella Pessi +2 more
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Identification of Key Factors for Anoxic Survival of B. cenocepacia H111. [PDF]
Int J Mol Sci, 2022 Burkholderia cenocepacia is an opportunistic pathogen that can lead to severe infections in patients suffering from cystic fibrosis (CF) and chronic granulomatous disease. Being an obligate aerobe, B. cenocepacia is unable to grow in the absence of oxygen. In this study, we show that the CF isolate B.
Paszti S +7 more
europepmc +4 more sources
Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient Lung [PDF]
Frontiers in Microbiology, 2020 During chronic respiratory infections of cystic fibrosis (CF) patients, bacteria adaptively evolve in response to the nutritional and immune environment as well as influence other infecting microbes.
A. Amir Hassan +5 more
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The mechanism of action of auranofin analogs in <i>B. cenocepacia</i> revealed by chemogenomic profiling. [PDF]
Microbiol SpectrABSTRACT Drug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scavenges reactive oxygen species (ROS).
Maydaniuk DT +10 more
europepmc +4 more sources
Characterization of the Antibiotic and Copper Resistance of Emergent Species of Onion-Pathogenic Burkholderia Through Genome Sequence Analysis and High-Throughput Sequencing of Differentially Enriched Random Transposon Mutants [PDF]
PathogensThe prevalence of antimicrobial resistance (AMR) in bacterial pathogens resulting from the intensive usage of antibiotics and antibiotic compounds is acknowledged as a significant global concern that impacts both human and animal health.
Jonas J. Padilla +3 more
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The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111. [PDF]
PLoS One, 2014 In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA.
Aguilar C +4 more
europepmc +6 more sources
Frontiers in Microbiology, 2018 The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis +2 more
exaly +3 more sources
Unraveling Burkholderia cenocepacia H111 fitness determinants using two animal models [PDF]
mSystemsBurkholderia cenocepacia is an opportunistic pathogen that has been associated with nosocomial outbreaks in hospitals and can cause severe respiratory infections among immunocompromised patients and individuals suffering from cystic fibrosis.
Sarah Paszti +5 more
doaj +2 more sources
<i>In vitro</i> untargeted polar metabolomics data from <i>B. cenocepacia</i> and <i>S. aureus</i> biofilm supernatants. [PDF]
Microbiol Resour AnnouncABSTRACT Here, we offer a metabolomics dataset generated via high-performance liquid chromatography and high-resolution mass spectrometry analysis of in vitro biofilm supernatant harvested from the human pathogens Burkholderia cenocepacia and
Skaggs H, Yoder-Himes DR.
europepmc +3 more sources