Results 31 to 40 of about 12,361,159 (162)

Genomic analyses of Burkholderia cenocepacia reveal multiple species with differential host-adaptation to plants and humans

BMC Genomics, 2019
Background Burkholderia cenocepacia is a human opportunistic pathogen causing devastating symptoms in patients suffering from immunodeficiency and cystic fibrosis. Out of the 303 B.
Adrian Wallner, Eoghan King, Eddy L. M. Ngonkeu, Lionel Moulin, Gilles Béna   +4 more
doaj   +1 more source

The changing epidemiology of Burkholderia species infection at an adult cystic fibrosis centre [PDF]

, 2008
Background: This study reviews the impact of changing infection control practices at the Manchester Adult Cystic Fibrosis Centre (MACFC) upon the epidemiology of Burkholderia species infections.Methods: We reviewed strain and genomovar typing of all ...
Doherty, Catherine J., Govan, John R., Dodd, Mary E., Webb, A. K., Jones, Andrew M., France, Megan W.   +5 more
core   +1 more source

Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia

BMC Genomics, 2009
Background Burkholderia cenocepacia belongs to a group of closely related organisms called the B. cepacia complex (Bcc) which are important opportunistic human pathogens. B.
Malott Rebecca J, Viteri Duber F, O'Grady Eoin P, Sokol Pamela A   +3 more
doaj   +1 more source

Burkholderia PglL enzymes are Serine preferring oligosaccharyltransferases which target conserved proteins across the Burkholderia genus

Communications Biology, 2021
Hayes et al provide a glycosylation site focused analysis of the glycoproteome of two widely utilized B. cenocepacia strains, K56-2 and H111. This team demonstrates that within these glycoproteomes Serine is the sole residue targeted for protein ...
Andrew J. Hayes, Jessica M. Lewis, Mark R. Davies, Nichollas E. Scott   +3 more
doaj   +1 more source

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1 beta production in macrophages [PDF]

, 2010
Burkholderia cenocepacia infections in CF patients involve heightened inflammation, fatal sepsis, and high antibiotic resistance. Proinflammatory IL-1 beta secretion is important in airway inflammation and tissue damage.
Sheetal Kotrange, Kyle Caution, Akhter, A., Abdelaziz, D., Basant Abdulrahman, Mark D Wewers, Amal O Amer, Loutet, S.A., Kopp, B., Anwari Akhter, Mccoy, K., Benjamin Kopp, Abu Khweek, A., Abdulrahman, B., Valvano, Miguel; id_orcid, Arwa Abu Khweek, Ximena Ortega, Kotrange, S., Karen McCoy, Amer, A.O., Abu Khweek, Arwa, Marsh, C., Slade A Loutet, Clay Marsh, Miguel A Valvano, Wewers, M.D., Ortega, X., Caution, K., Dalia Abdelaziz   +28 more
core   +1 more source

A c-di-GMP-Modulating Protein Regulates Swimming Motility of Burkholderia cenocepacia in Response to Arginine and Glutamate

Frontiers in Cellular and Infection Microbiology, 2018
Burkholderia cenocepacia is an opportunistic bacterium that can thrive in different environments, including the amino acid-rich mucus of the cystic fibrosis (CF) lung. B.
Brijesh Kumar, John L. Sorensen, Silvia T. Cardona, Silvia T. Cardona   +3 more
doaj   +1 more source

Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
The human microbiome mediates immune homeostasis and metabolic signaling across organs. Beyond the gut‐lung axis, crosstalk between the lung and other organ systems is less recognized. This review assesses the axial connectivity of the lung microbiome across the gut, brain, skin, heart, kidney, and liver.
Mathangi Palanivel, Jayanth Kumar Narayana, Sanjay H. Chotirmall   +2 more
wiley   +1 more source

Candidate essential genes in Burkholderia cenocepacia J2315 identified by genome-wide TraDIS

Frontiers in Microbiology, 2016
Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. However, antibiotic therapy rarely results in complete eradication of the pathogen due to its intrinsic resistance to many clinically available ...
Yee-Chin Wong, Moataz Abd El Ghany, Raeec Naeem, Kok-Wei lee, Yung-Chie Tan, Arnab Pain, Sheila Nathan   +6 more
doaj   +1 more source

Two distinct alcohol dehydrogenase classes mediate bacterial 2‐hydroxyethylphosphonate catabolism

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Phosphonates are molecules containing a direct carbon‐phosphorus bond. In nature, these compounds are produced by a variety of organisms, and many environmental microbes are able to degrade specific phosphonates and feed on them. This work focuses on 2‐hydroxyethylphosphonate (HEP)—a natural compound that is found frequently in the environment,
Francesca Piazza, Marianna Rodella, Nicholas Salanti, Giovanni Merici, Elisa Rossi, Claudio Rivetti, Florian Götzinger, Katharina Pallitsch, Alessio Peracchi   +8 more
wiley   +1 more source

CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.

, 2014
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF).
Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Chu, Karen KY, Khaenam, Prasong, Rinchai, Darawan, Maillere, Bernard, Robinson, John H, Favry, Emmanuel, Bancroft, Gregory J, Reynolds, Catherine J, Altmann, Daniel M, Spink, Natasha, Boyton, Rosemary J, Musson, Julie A, De Soyza, Anthony   +14 more
core   +1 more source