Results 61 to 70 of about 4,634 (162)

IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages.

PLoS ONE, 2014
Burkholderia cenocepacia is a virulent pathogen that causes significant morbidity and mortality in patients with cystic fibrosis (CF), survives intracellularly in macrophages, and uniquely causes systemic infections in CF.
Kaivon Assani, Mia F Tazi, Amal O Amer, Benjamin T Kopp   +3 more
doaj   +1 more source

Characterisation and In Planta Activity of Bacteriophages That Infect the Key Bacterial Species Associated With Acute Oak Decline

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Phages that infect the oak pathogens Brenneria goodwinii and Gibbsiella quercinecans were isolated. The phages were able to effectively reduce bacterial populations of their respective hosts in vitro. However, when applied in planta, the phages did not reduce host populations and instead phages and bacteria co‐existed over time.
Emily R. Grace, Vanja Milenkovic, Katherine G. Hinton, Sabrine Dhaouadi, Diana Vinchira‐Villarraga, Michael A. Brockhurst, Mojgan Rabiey, Robert W. Jackson   +7 more
wiley   +1 more source

The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients [PDF]

AMB Express, 2016
تظل التهابات الجهاز التنفسي التي تسببها بكتيريا عقدة بوركهولديريا سيباسيا (Bcc) سببًا مهمًا للاعتلال والوفيات بين مرضى التليف الكيسي، مما يسلط الضوء على الحاجة إلى استراتيجيات علاجية جديدة. في العمل الحالي، درسنا بروتين B. cenocepacia BCAL2958، وهو عضو في عائلة البروتينات الشبيهة بـ OmpA، والتي أثبتت أنها عالية المناعة في مسببات الأمراض الأخرى وقادرة ...
Sílvia A. Sousa, Mostafa Y. Morad, Joana R. Feliciano, Tiago Pita, Soad Nady, Rehab E. El‐Hennamy, Mona Abdel-Rahman, José E. Cavaco, Luí­sa Álvares Pereira, Celeste Barreto, Jorge H. Leitão   +10 more
openaire   +3 more sources

Glycoproteomic and proteomic analysis of Burkholderia cenocepacia reveals glycosylation events within FliF and MotB are dispensable for motility

Microbiology Spectrum
Across the Burkholderia genus O-linked protein glycosylation is highly conserved. While the inhibition of glycosylation has been shown to be detrimental for virulence in Burkholderia cepacia complex species, such as Burkholderia cenocepacia, little is ...
Jessica M. Lewis, Leila Jebeli, Pauline M. L. Coulon, Catrina E. Lay, Nichollas E. Scott   +4 more
doaj   +1 more source

Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2

BMC Microbiology, 2009
Background Metabolically versatile soil bacteria Burkholderia cepacia complex (Bcc) have emerged as opportunistic pathogens, especially of cystic fibrosis (CF).
Hamlin Jason NR, Bloodworth Ruhi AM, Cardona Silvia T   +2 more
doaj   +1 more source

Chloroplast‐ and mitochondrion‐specific random C‐to‐T mutagenesis for forward genetics of organelle genomes

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Nanami Kosaka, Yoshiki Harada, Issei Nakazato, Miki Okuno, Takehiko Itoh, Nobuhiro Tsutsumi, Shin‐ichi Arimura   +6 more
wiley   +1 more source

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network

Tropical Medicine &International Health, Volume 31, Issue 4, Page 547-559, April 2026.
ABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Oleg N. Reva, Anthony Sifuna, Francis Orata, Caroline Omolo, Jacob Stanley Iramiot, Mark C. Enright, Awelani Mutshembele, Jian Zhou, William A. Shivoga   +8 more
wiley   +1 more source

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan, Marlus Chorilli   +3 more
wiley   +1 more source

Elucidation of the B urkholderia cenocepacia hopanoid biosynthesis pathway uncovers functions for conserved proteins in hopanoid‐producing bacteria [PDF]

Environmental Microbiology, 2014
Summary Hopanoids are bacterial surrogates of eukaryotic membrane sterols and among earth's most abundant natural products. Their molecular fossils remain in sediments spanning more than a billion years.
Crystal L. Schmerk, Paula V. Welander, Mohamad A. Hamad, Katie L. Bain, Mark A. Bernards, Roger E. Summons, Miguel A. Valvano   +6 more
openaire   +1 more source

Extracellular Particles Derived From Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT The World Health Organization and the U.S. Centre for Disease Control and Prevention have reported that antibiotic‐resistant infections with Pseudomonas aeruginosa present a significant health risk worldwide. In the genetic disease Cystic Fibrosis (CF), chronic antibiotic‐resistant Pseudomonas lung infections and persistent inflammation remain
Sharanya Sarkar, Roxanna Barnaby, Zachary Faber, Lily Taub, Carolyn Roche, Lily A. Charpentier, Thomas H. Hampton, Brad Vietje, Douglas J. Taatjes, Byoung‐Kyu Cho, Young Ah Goo, Matthew J. Wargo, Daniel J. Weiss, Tracey L. Bonfield, Thomas J. Kelley, Bruce A. Stanton   +15 more
wiley   +1 more source