Results 51 to 60 of about 600,274 (298)

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells

Journal of Experimental Medicine, 2017
Identification of germinal center (GC) B cells is typically reliant on the use of surface activation markers that exhibit a wide range of expression. Here, we identify Ephrin-B1, a ligand for Eph-related receptor tyrosine kinases, as a specific marker of
B. Laidlaw, T. Schmidt, Jesse A. Green, Christopher D. C. Allen, T. Okada, J. Cyster   +5 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis

Journal of Cell Biology, 2018
There is remarkable redundancy between the Cyclin–Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions ...
Bernhard Strauss, A. Harrison, P. A. Coelho, K. Yata, M. Zernicka-Goetz, J. Pines   +5 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

Nature Communications, 2018
Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a yet unknown function.
Laura Pascual-Reguant, E. Blanco, Silvia Galan, François le Dily, Yasmina Cuartero, Gemma Serra-Bardenys, V. Di Carlo, Ane Iturbide, Joan Pau Cebrià-Costa, L. Nonell, A. G. de Herreros, L. Di Croce, M. Martí-Renom, S. Peiró   +13 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Photo-realistic traffic scene datasets: real and synthetic perspectives for vision-based analysisMendeley Data

Data in Brief
Perception plays a crucial role in autonomous driving and computer vision, particularly in interpreting traffic scenes from monocular cameras. In this article, we present a comprehensive collection of traffic scene datasets organized into four distinct ...
Khulan Khalzaa, Stephen Karungaru, Kenji Terada, Tsend-Ayush Chimed-Ochir   +3 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Distribution records and extended range of the Sri Lanka Frogmouth Batrachostomus moniliger (Aves: Caprimulgiformes: Podargidae) in the Western Ghats: a review from 1862 to 2015

Journal of Threatened Taxa, 2016
The Sri Lanka Frogmouth (or Ceylon Frogmouth) Batrachostomus moniliger is an endemic resident bird confined to the evergreen and secondary forests of Sri Lanka and the Western Ghats of India.
Anil Mahabal, Sanjay Thakur, Rajgopal Patil   +2 more
doaj   +1 more source

Prevalent reliance of bacterioplankton on exogenous vitamin B1 and precursor availability

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Virtually all organisms require vitamin B1, including bacterioplankton that impact nutrient cycling and productivity in aquatic systems and Earth’s climate.
R. Paerl, J. Sundh, Demeng Tan, S. Svenningsen, S. Hylander, Jarone Pinhassi, Anders F. Andersson, L. Riemann   +7 more
semanticscholar   +1 more source