Results 21 to 30 of about 1,188,690 (195)

Detrimental Effects of Helium Ion Irradiation on Cognitive Performance and Cortical Levels of MAP-2 in B6D2F1 Mice. [PDF]

Int J Mol Sci, 2018
The space radiation environment includes helium (4He) ions that may impact brain function. As little is known about the effects of exposures to 4He ions on the brain, we assessed the behavioral and cognitive performance of C57BL/6J × DBA2/J F1 (B6D2F1) mice three months following irradiation with 4He ions (250 MeV/n; linear energy transfer (LET) = 1.6 ...
Raber J, Torres ERS, Akinyeke T, Lee J, Weber Boutros SJ, Turker MS, Kronenberg A.   +6 more
europepmc   +6 more sources

Development, Live Birth and Fertility in Mouse Oocytes Penetrated by Spermatids Exposed to the HDAC Inhibitor Scriptaid. [PDF]

Reprod Med Biol
ABSTRACT Purpose In mouse embryos derived from round spermatid injection (ROSI), low developmental potential due to abnormal histone modification is improved by histone deacetylase (HDAC) inhibitors. However, some studies suggest that the use of such inhibitors leads to the birth of hypomorphic offspring.
Watanabe S, Takemoto Y, Inoue R, Tanaka I, Miyata H, Makino Y, Nagayoshi M, Nakajima D, Fujimoto S, Tanaka A.   +9 more
europepmc   +2 more sources

B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. [PDF]

J Gerontol A Biol Sci Med Sci, 2009
To determine if B6D2F1 mice represent a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation (EDD) with aging, mice were studied at 6.9 +/- 0.3 and 31.9 +/- 0.6 months. EDD to acetylcholine (ACh) was 26% (p < .001) and 12% (p < .001) lower, respectively, in isolated carotid (n = 10-11) and femoral (n = 10) arteries from ...
Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR.   +6 more
europepmc   +4 more sources

Oocyte Age-Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes. [PDF]

Aging Cell
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Dudko N, Ilcikova T, Novotna N, Czernik M, Loi P, Fulka J, Bhattacharjee P, Santoro R, Fulka H.   +8 more
europepmc   +2 more sources

Reactivation of Coccidioidomycosis in a Mouse Model of Asymptomatic Controlled Disease

Journal of Fungi, 2022
The majority of human coccidioidomycosis infections are asymptomatic or self-limited but may have sequestered spherules in highly structured granulomas. Under immunosuppression, reactivation of fungal growth can result in severe disease.
Lisa F. Shubitz, Daniel A. Powell, Sharon M. Dial, Christine D. Butkiewicz, Hien T. Trinh, Amy P. Hsu, Adam Buntzman, Jeffrey A. Frelinger, John N. Galgiani   +8 more
doaj   +1 more source

Ensaio de potência da alfaepoetina: Comparação de camundongos Swiss Webster, NIH, C57BL/6, BALB/c com o híbrido B6D2F1 /Potency assay of epoetin alpha: Comparison of Swiss Webster, NIH, C57BL/6, BALB/c mice with the hybrid B6D2F1

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2013
Neste estudo comparamos os resultados de ensaios de potência da alfaepoetina (EPOhr) realizados com camundongos de diferentes colônias e linhagens (Swiss Webster, NIH, C57BL/6 e BALB/c) com aqueles de ensaios conduzidos com o híbrido B6D2F1, o úni-co ...
Igor Barbosa da Silva, Paulo César Dick, Katherine Antunes de Mattos, Alessandra Santos Almeida , Ricardo Gonçalves Silva, Darcy Akemi Hokama, Francisco José Roma Paumgartten   +6 more
doaj   +1 more source

A comparison study of superovulation strategies for C57BL/6J and B6D2F1 mice in CRISPR-Cas9 mediated genome editing [PDF]

Reproduction, Fertility and Development, 2021
Reproductive techniques such as superovulation and in vitro fertilisation (IVF) have been widely used in generating genetically modified animals. The current gold standard for superovulation in mice is using coherent treatments of equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG).
Xue Zhao, Johnny X. Huang, Hailong Zhang, Xueyang Gong, Jinhua Dong, Hong-Lin Ren, Zengshan Liu   +6 more
openaire   +4 more sources

Stabilization of serum antibody responses triggered by initial mucosal contact with the antigen independently of oral tolerance induction

Brazilian Journal of Medical and Biological Research, 2001
Initial contacts with a T-dependent antigen by mucosal routes may result in oral tolerance, defined as the inhibition of specific antibody formation after subsequent parenteral immunizations with the same antigen.
B.A. Verdolin, S.M. Ficker, A.M.C. Faria, N.M. Vaz, C.R. Carvalho   +4 more
doaj   +1 more source

Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse

BMC Cell Biology, 2001
Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents such as 17β-estradiol. This study investigated
Kumar Vinay, Bennett Michael, Gruber Helen E, Puzanov Igor J, Gordon Brian   +4 more
doaj   +1 more source

Testis-Enriched F-Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice. [PDF]

Andrology
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Kaneda Y, Miyata H, Ikawa M.
europepmc   +2 more sources