Results 31 to 40 of about 1,188,690 (195)

The TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-interleukin-27 antibody for maximal protection and regulatory T-cell upregulation

open access: yesHaematologica, 2019
In spite of considerable therapeutic progress, acute graft-versus-host disease still limits allogeneic hematopoietic cell transplantation. We recently reported that mouse infection with nidovirus lactate dehydrogenase elevating virus impairs disease in ...
Mélanie Gaignage   +6 more
doaj   +1 more source

An Exploration of Molecular Correlates Relevant to Radiation Combined Skin-Burn Trauma. [PDF]

open access: yesPLoS ONE, 2015
Exposure to high dose radiation in combination with physical injuries such as burn or wound trauma can produce a more harmful set of medical complications requiring specialist interventions.
Aminul Islam   +3 more
doaj   +1 more source

Efficient chimeric mouse production using a novel embryonic stem cell line

open access: yesВавиловский журнал генетики и селекции, 2017
Embryonic stem cells are commonly used for generation of transgenic mice. Embryonic stem cells could participate in the development of chimeric animals after injection into a blastocyst.
G. V. Kontsevaya   +6 more
doaj   +1 more source

BCGΔBCG1419c increased memory CD8+ T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis

open access: yesScientific Reports, 2022
Previously, we reported that a hygromycin resistant version of the BCGΔBCG1419c vaccine candidate reduced tuberculosis (TB) disease in BALB/c, C57BL/6, and B6D2F1 mice infected with Mycobacterium tuberculosis (Mtb) H37Rv.
Kee Woong Kwon   +6 more
doaj   +1 more source

Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity. [PDF]

open access: yesPLoS ONE, 2006
Variation between inbred mice of susceptibility to experimental Trypanosoma cruzi infection has frequently been described, but the immunogenetic background is poorly understood.
Sebastian E B Graefe   +6 more
doaj   +1 more source

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice. [PDF]

open access: yesAndrology
Abstract Background RIBC1 (RIB43A domain with coiled‐coils 1) and RIBC2 (RIB43A domain with coiled‐coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo‐electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs ...
Katsuma K   +7 more
europepmc   +2 more sources

Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function

open access: yesJournal of Immunology Research, 2018
Transfer of splenocytes isolated from B6 mice into normal B6D2F1 mice induces acute graft-versus-host disease (aGVHD), resulting in the expansion of donor cytotoxic T lymphocytes that eliminate recipient B cells. The cytokine IL-22, secreted by Th1 cells,
Jianbo Wu   +6 more
doaj   +1 more source

Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice

open access: yesReproductive Medicine and Biology, 2022
Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma   +8 more
doaj   +1 more source

Early markers of phenotypic heterogeneity in the induced model of systemic lupus erythematosus

open access: yesБюллетень сибирской медицины, 2018
The study aimed at evaluating the predisposition for development of different variants of SLE based on an inflammatory response in intact mice.Materials and methods.
O. P. Kolesnikova   +4 more
doaj   +1 more source

Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains

open access: yesAnimals, 2022
Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under discussion which temperature is more appropriate and whether the commonly used room temperature in ...
Thomas Kolbe   +5 more
doaj   +1 more source

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