Results 61 to 70 of about 22,003 (134)

Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer? [PDF]

, 2014
Immunotherapy has been studied for many years in lung cancer without significant results, making the majority of oncologists quite skeptical about its possible application for non-small cell lung cancer treatment.
Annelies Janssens, Antonio Russo, Blixt O, Bolli M, Brichard VG, Christian Rolfo, Decoster L, Digumarti R, Dy GK, Eager R, Echchakir H, Edgardo S Santos, Evelien Smits, Francesco Passiglia, Gail MH, Gancz D, Giovanni Sortino, Giuseppe Bronte, Grosso J, Grunwald C, Hamanaka Y, Hirasawa Y, Hirsh V, Ho SB, Igney FH, Kavanagh B, Lee JC, Lopez PH, Luis Raez, Ma PC, Manegold C, Marta Castiglia, Merlo V, Nagata S, Nemunaitis J, Nemunaitis J, Neninger Vinageras E, O’Brien ME, Parikh PM, Patrick Pauwels, Petersen RP, Ramalingam S, Robert C, Rodriguez PC, Salgia R, Schimmer AD, Segatori VI, Sienel W, Spadaro M, Takahashi K, Takenoyama M, van Cruijsen H, Zou W   +52 more
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mRNA Vaccines: Current Applications and Future Directions

MedComm, Volume 6, Issue 11, November 2025.
mRNA vaccines represent an innovative platform that leverages messenger RNA technology to direct cells to produce specific antigens, thereby eliciting an immune response. mRNA vaccines offer high programmability and significantly improved stability and immunogenicity through nucleotide modifications and delivery systems such as lipid nanoparticles ...
Jianmei Li, Yixin Liu, Jie Dai, Li Yang, Feng Xiong, Jing Xia, Jing Jin, Yangping Wu, Xingchen Peng   +8 more
wiley   +1 more source

CD28 Ligation Increases Macrophage Suppression of T Cell Proliferation [PDF]

, 2012
When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to actively suppress the T cell response.
Bartlett, Thomas, Bucknum, Amanda, Composto, Gabriella, Cua, Jackelyn, Kozlowski, Megan, Riggs, James E., Sharpe, Arlene Helen, Silberman, Daniel, Somerville, John E., Walker, Amanda, Werda, Amy   +10 more
core   +1 more source

Developing a Personalized Cancer Nanovaccine Using Coxsackievirus‐Reprogrammed Cancer Cell Membranes for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 12, Issue 40, October 27, 2025.
A personalized nanovaccine combining PLGA‐encapsulated heat‐inactivated CVB3 and membranes from CVB3‐infected breast cancer cells stimulates potent antitumor immunity. It reduces immunosuppressive markers, enhances immune activation, and improves survival in vivo.
Amirhossein Bahreyni, Yasir Mohamud, Amrit Singh, Razieh Sadat Banijamali, Jeffrey Tang, Jingchun Zhang, Honglin Luo   +6 more
wiley   +1 more source

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [PDF]

, 2018
Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair.
Achuthan, Alivernini, Alivernini, Alvaro-Gracia, Anderson, Asquith, Bamboat, Behrens, Bell, Ben Nasr, Benham, Black, Bluml, Brentano, Burmester, Burmester, Burmester, Catrina, Cauli, Cheung, Chu, Chu, Couzin-Frankel, Cramer, Cross, den Berg, den Brand, Dillon, Donlin, Ehrenstein, Elmesmari, Ferraccioli, Field, Firestein, Frank-Bertoncelj, Gao, Ginhoux, Greven, Guiducci, Guo, Hambleton, Hamilton, Haschka, Herenius, Hogg, Hurst, Iliev, James, Jongbloed, Kaplanski, Kokkonen, Kollias, Konig, Kriegler, Kurowska-Stolarska, Kurowska-Stolarska, Kurowska-Stolarska, Lemke, Malmstrom, Mann, McInnes, McInnes, McInnes, McLoughlin, Midwood, Miller, Misharin, Misso, Moret, Moret, Morton, Murata, Na, Nagy, Nassar, Ng, O'Connell, O'Connell, O'Keeffe, Ohshima, Okada, Paolino, Park, Rajasekhar, Ramwadhdoebe, Rauber, Reynolds, Roberts, Rothlin, Rupaimoole, Rycke, Sacre, Schett, Singh, Smith, Smith, Smolen, Sokolove, Stanczyk, Steidl, Takeuchi, Tannahill, Thai, Tsoumakidou, Udalova, Vandenabeele, Villani, Watts, Weinblatt, Weiss, Williamson, Wolf, Xiong, Yeo, Yu, Zou   +115 more
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The Role of the PD-1 Immunoreceptor in Pregnancy [PDF]

, 2008
During pregnancy, the maternal immune system must be carefully modulated as the fetus is immunologically foreign to her leukocytes. We propose that the CD28 family immune receptor, PD-1, functions during pregnancy to control maternal immune reactions. PD-
Taglauer, Elizabeth Susan
core  

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses [PDF]

, 2005
B7-DC, one of the recently described B7 family members, has the capacity to inhibit T cell responses via engagement of the immunoreceptor tyrosine-based inhibitory motif–containing inhibitory PD-1 receptor as well as enhance responses via an as yet ...
Chen, Lieping, Crafton, Emily B., Housseau, Franck, Koseki, Haruhiko, Pardoll, Drew M., Schulick, Richard D., Shin, Tahiro, Shin, Takako, Tsuchiya, Haruo, Yoshimura, Kiyoshi   +9 more
core   +2 more sources

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

The Invisible Lens: Why Theoretical Models Are Essential for Interpreting Immune Phenomena

Scandinavian Journal of Immunology, Volume 102, Issue 4, October 2025.
ABSTRACT Immunology progresses not merely by accumulating data but by evolving the conceptual lenses through which those data are interpreted; yet for six decades the self–non‐self/infectious‐non‐self (SNS/INS) paradigm—casting allogeneity as activating signal and ‘self’ as intrinsically tolerogenic—has dominated research design, peer review and ...
Masoud H. Manjili
wiley   +1 more source

Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment [PDF]

, 2016
Blockade of the programmed-death 1 receptor (PD-1)/programmed-death ligand (PD-L1) pathway efficiently reduces tumour growth and improves survival. Durable tumour regression with blockade of the PD-1/PD-L1 checkpoint has been demonstrated in recent ...
Bou-Gharios, George, Hirai, Mariko, Kato, Koroku, Kawashiri, Shuichi, Kitahara, Hiroko, Kobayashi, Yutaka, Nakamura, Hiroyuki   +6 more
core   +1 more source