Results 211 to 220 of about 3,011 (240)

Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells

Tissue Antigens, 2007
AbstractB and T lymphocyte attenuator (BTLA) has been recently identified as a new inhibitory receptor of the CD28 superfamily, with similarities to cytotoxic T lymphocyte activation antigen (CTLA)‐4 and programmed death (PD)‐1. Engagement of BTLA on T lymphocytes can profoundly reduce the T cell receptor (TCR)‐mediated activation.
X-F, Wang   +10 more
exaly   +3 more sources

B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis

Graefe's Archive for Clinical and Experimental Ophthalmology, 2011
To investigate the roles that B and T lymphocyte attenuator (BTLA) and herpesvirus entry mediator (HVEM) play in the development of antigen-induced experimental conjunctivitis (EC).BALB/c mice were immunized with ragweed (RW) in alum. Ten days later, the mice were challenged with RW in eye drops. After 24 hours, the conjunctivas, blood and spleens were
Hideo Yagita   +2 more
exaly   +3 more sources

Targeting B and T lymphocyte attenuator in cancer immunotherapy

International Journal of Biological Macromolecules
B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor of B7 family that shares structural homology with cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and programmed death-1 (PD-1). Overlapping BTLA binding sites in herpes virus entry mediator (HVEM) for different ligand/receptor interactions including CD160 and herpes simplex virus ...
Keywan Mortezaee
exaly   +3 more sources

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

Nature Immunology, 2004
B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and T cells. Previously, indirect observations suggested that B7x was a ligand for BTLA. Here we show that BTLA does not bind B7x; instead, we identify herpesvirus entry mediator (HVEM) as the unique BTLA ligand.
Theresa Murphy   +2 more
exaly   +3 more sources

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