Results 221 to 230 of about 3,011 (240)

Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells

Biochemical and Biophysical Research Communications, 2006
Co-signal receptors provide crucial activating or attenuating signals for T cells. The B and T lymphocyte attenuator (BTLA/CD272) is a third member of co-inhibitory receptors, which belongs to the CD28 immunoglobulin-superfamily. Using monoclonal antibodies (mAbs) against human BTLA, we show that BTLA is constitutively expressed on most CD4+ and CD8+ T
Noriko, Otsuki, Yousuke, Kamimura, Masaaki, Hashiguchi, Miyuki, Azuma   +3 more
openaire   +2 more sources

The Function of B and T Lymphocyte Attenuator and Its Role in Transplantation

APMIS
ABSTRACTImmune checkpoints are important molecules that regulate the immune response, preventing its overactivation from causing tissue damage and autoimmune diseases. B and T lymphocyte attenuator (BTLA) plays an important role in regulating the activation and suppression of the immune response as part of a bidirectional signaling complex.
Kai Ma, Heqiao Han, Yuchen Bao, Rongtao Chen, Yixuan Yang, Wenwei Shao   +5 more
openaire   +2 more sources

B and T lymphocyte attenuator tempers early infection immunity (133.6)

The Journal of Immunology, 2009
Abstract Co-inhibitory pathways are thought to act in later stages of an adaptive immune response, but whether co-inhibition contributes to early innate immunity is unclear. We show that engagement of the newly discovered co-inhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) is critical for ...
Nicholas K. Brown, Yonglian Sun, Mendy Miller, Yang-Xin Fu   +3 more
openaire   +1 more source

B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation

Nature Immunology, 2007
B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell activation, but its function in vivo is not well characterized. Here we show that mice deficient in full-length BTLA or its ligand, herpesvirus entry mediator, had increased number of memory CD8(+) T cells.
Carsten, Krieg, Onur, Boyman, Yang-Xin, Fu, Jonathan, Kaye   +3 more
openaire   +2 more sources

A role for B and T lymphocyte attenuator in regulating T cell responses during Tuberculosis (P3088)

The Journal of Immunology, 2013
Abstract B and T lymphocyte attenuator (BTLA) (CD272) is a coinhibitory receptor expressed by most leukocytes, with the highest expression levels observed on T and B cells, and is involved in the maintenance of peripheral tolerance by dampening the activation of lymphocytes.
Ajay Grover, Jolynn Troudt, Chad Foster, Nick May, Angelo Izzo   +4 more
openaire   +1 more source

B and T lymphocyte attenuator (BTLA)

Science-Business eXchange, 2014
openaire   +1 more source

Beating (T-lymphocyte driven) atherosclerosis with B- and T-lymphocyte attenuator

Cardiovascular Research, 2020
Andrew Sage, Meritxell Edurne Nus Chimeno, Ziad Mallat   +2 more
exaly  

Serum levels of soluble B and T lymphocyte attenuator predict overall survival in patients undergoing immune checkpoint inhibitor therapy for solid malignancies

International Journal of Cancer, 2021
Frank Tacke, Fabian Beier, Jakob Nikolas Kather   +2 more
exaly  

The Abnormal Expression of B and T Lymphocyte Attenuator in Patients with Myelodysplastic Syndromes

Leukemia Research, 2017
S. Geng, J. Weng, M. Lin, P. Wu, C. Deng, Z. Lu, X. Huang, P. Lai, H. Zhang, X. Du   +9 more
openaire   +1 more source

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

Proceedings of the National Academy of Sciences of the United States of America, 2005
Wenjun Ouyang, Kelly M Loyet, Lino Gonzalez   +2 more
exaly