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抗BTLA(B and T Lymphocyte Attenuator)抗体(3C10)によるマウス心臓移植片の生着延長効果とIL-10依存性CD4+制御性T細胞の誘導
抗BTLA(B and T Lymphocyte Attenuator)抗体(3C10)によるマウス心臓移植片の生着延長効果とIL-10依存性CD4+制御性T細胞の誘導openaire +1 more source
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Journal of Immunology, 2012
Abstract IPF is an interstitial lung disease that affects over 128,000 people in the U.S., has a yearly mortality of 48,000, and has no effective treatment. Current theories on the etiology of IPF have not focused on the role of the immune system due to the inefficacy of steroid therapy.
Stephenie Takahashi +5 more
exaly +3 more sources
Abstract IPF is an interstitial lung disease that affects over 128,000 people in the U.S., has a yearly mortality of 48,000, and has no effective treatment. Current theories on the etiology of IPF have not focused on the role of the immune system due to the inefficacy of steroid therapy.
Stephenie Takahashi +5 more
exaly +3 more sources
Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells
Biochemical and Biophysical Research Communications, 2006Co-signal receptors provide crucial activating or attenuating signals for T cells. The B and T lymphocyte attenuator (BTLA/CD272) is a third member of co-inhibitory receptors, which belongs to the CD28 immunoglobulin-superfamily. Using monoclonal antibodies (mAbs) against human BTLA, we show that BTLA is constitutively expressed on most CD4+ and CD8+ T
Noriko, Otsuki +3 more
openaire +3 more sources
Gut, 2012
Objectives Fulminant viral hepatitis (FH) remains a serious clinical problem for which the underlying pathogenesis remains unclear. The B and T lymphocyte attenuator (BTLA) is an immunoglobulin-domain-containing protein that has the capacity to maintain peripheral tolerance and limit immunopathological damage ...
Chengying, Yang +11 more
openaire +3 more sources
Objectives Fulminant viral hepatitis (FH) remains a serious clinical problem for which the underlying pathogenesis remains unclear. The B and T lymphocyte attenuator (BTLA) is an immunoglobulin-domain-containing protein that has the capacity to maintain peripheral tolerance and limit immunopathological damage ...
Chengying, Yang +11 more
openaire +3 more sources
Blood, 2013
Background and Aims Human T-lymphotropic virus type 1(HTLV-1) infection is a retroviral infection with varied manifestations, either clinically asymptomatic carriers (AC) or symptomatic with about 1-5% developing the hematological manifestation, Adult T cell lymphoma/leukemia (ATLL).
Chioma Ezinne Chibueze +1 more
semanticscholar +3 more sources
Background and Aims Human T-lymphotropic virus type 1(HTLV-1) infection is a retroviral infection with varied manifestations, either clinically asymptomatic carriers (AC) or symptomatic with about 1-5% developing the hematological manifestation, Adult T cell lymphoma/leukemia (ATLL).
Chioma Ezinne Chibueze +1 more
semanticscholar +3 more sources
Targeting B and T lymphocyte attenuator in cancer immunotherapy
International Journal of Biological MacromoleculesB and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor of B7 family that shares structural homology with cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and programmed death-1 (PD-1).
Keywan Mortezaee
exaly +2 more sources
Journal of Immunology, 2010 We recently showed that mice lacking B and T lymphocyte attenuator (BTLA), a third inhibitory coreceptor expressed on B cells and T cells, exhibit an increased Ag-specific IgG response and gradually develop hyper-γ–globulinemia and autoantibody ...
D. Kashiwakuma +10 more
semanticscholar +2 more sources