Results 11 to 20 of about 31,156,887 (403)

AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins

Biomolecules, 2021
An inappropriate response to progestogens in the human endometrium can result in fertility issues and jeopardize progestin-based treatments against pathologies such as endometriosis.
Charlotte Thieffry, Marie Van Wynendaele, Asena Aynaci, Mauriane Maja, Caroline Dupuis, Axelle Loriot, Etienne Marbaix, Patrick Henriet   +7 more
doaj   +1 more source

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein

Human Vaccines & Immunotherapeutics, 2020
The small hydrophobic (SH) glycoprotein of human respiratory syncytial virus (RSV) is a transmembrane protein that is poorly accessible by antibodies on the virion but has an ectodomain (SHe) that is accessible and expressed on infected cells.
Heather L. Torrey, Valarmathy Kaliaperumal, Yogesh Bramhecha, Genevieve M. Weir, Ann R. Falsey, Edward E. Walsh, Joanne M. Langley, Bert Schepens, Xavier Saelens, Marianne M. Stanford   +9 more
doaj   +1 more source

Role of B cell activating factor in the development of periodontitis

口腔疾病防治, 2020
B cell activating factor (BAFF) is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases.
ZHANG Zheng, WANG Zuomin
doaj   +1 more source

The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases

Autoimmunity, 2023
The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration.
Yunfei Li, Min Ming, Chunyang Li, Songpo Liu, Dan Zhang, Tao Song, Jun Tan, Jidong Zhang   +7 more
doaj   +1 more source

Whatever will B cell be? [PDF]

Nature Reviews Immunology, 2015
Individual naive B cells show heterogeneity in their response to antigen-mediated activation.
openaire   +2 more sources

Tisagenlecleucel in Children and Young Adults with B‐Cell Lymphoblastic Leukemia

New England Journal of Medicine, 2018
Background In a single‐center phase 1–2a study, the anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children and ...
S. Maude, T. Laetsch, J. Buechner, S. Rives, M. Boyer, H. Bittencourt, P. Bader, M. Verneris, H. Stefanski, G. D. Myers, M. Qayed, B. De Moerloose, H. Hiramatsu, Krysta D Schlis, K. Davis, P. Martin, Eneida R. Nemecek, G. Yanik, C. Peters, A. Baruchel, N. Boissel, F. Mechinaud, A. Balduzzi, J. Krueger, C. June, B. Levine, P. Wood, T. Taran, M. Leung, K. Mueller, Yiyun Zhang, K. Sen, D. Lebwohl, M. Pulsipher, S. Grupp   +34 more
semanticscholar   +1 more source

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical

Autoimmunity, 2020
Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life.
Yu Feng, Ming Yang, Haijing Wu, Qianjin Lu   +3 more
doaj   +1 more source

The role of B cell osteoimmunity in periodontitis

口腔疾病防治, 2020
As the most important pathological feature of periodontitis, alveolar bone resorption also results in tooth loss and oral dysfunction. According to recent research, the host immune response is the major factor leading to alveolar bone resorption ...
LIN Xiaoping, HAN Yakun
doaj   +1 more source

Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]

Scandinavian Journal of Immunology, 2005
AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
Craig D. Milne, Christopher J. Paige, Yu Zhang   +2 more
openaire   +3 more sources