Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Identification of gene modules associated with B cell activation and tissue remodeling in primary Sjögren's syndrome. [PDF]
BMC ImmunolHuang J, Zhang C, Liu T, Deng Z, Liu L.
europepmc +1 more source
B cell activation via immunometabolism in systemic lupus erythematosus. [PDF]
Front Immunol, 2023 Iwata S, Hajime Sumikawa M, Tanaka Y.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma. [PDF]
Nat CommunKuliński TM +12 more
europepmc +1 more source
Activation of Toll-like receptor 4 by thyroid hormone triggers abnormal B-cell activation. [PDF]
Immun Inflamm Dis, 2023 Wang J +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. [PDF]
J Exp MedCalderón L +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The potential role of S-nitrosoglutathione reductase in astrocyte BAFF expression and B cell activation in experimental autoimmune encephalomyelitis. [PDF]
J NeuroimmunolWon J +5 more
europepmc +1 more source