Results 181 to 190 of about 2,252,807 (303)

B Cell Activation

Immunobiology, 1981
openaire   +1 more source

A PDK1-dependent regulation of PLCγ1 activation is essential for cancer cell migration and invasion

, 2011
PhDPhospholipase Cγ1 (PLCγ1) is highly expressed in several tumours such as breast carcinomas and has been found overexpressed in metastases compared to primary tumour in breast cancer patients, indicating that PLCγ1 may be important in tumourigenesis ...
Raimondi, Claudio
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

IgM-mediated protection drives early B-cell activation and mucosal containment of <i>Vibrio anguillarum</i> in Atlantic cod (<i>Gadus morhua)</i>. [PDF]

Front Immunol
Guslund NC, Jonsson A, Krabberød AK, López-Porras A, Nørstebø SF, Sørum H, Jakobsen KS, Johansen FE, Qiao SW.   +8 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Distinct Biomarker Profiles of B-Cell Activation in Metabolic and Viral Hepatic Fibrosis. [PDF]

Int J Mol Sci
Basile U, Carnazzo V, Basile V, Pignalosa S, D'Ambrosio F, Vinante I, Tagliaferro M, Niccolini B, Di Santo R, Rapaccini GL, Rosa E, De Spirito M, Marino M, Ciasca G.   +13 more
europepmc   +1 more source

Distinct metabolic requirements regulate B cell activation and germinal center responses. [PDF]

Nat Immunol, 2023
Sharma R, Smolkin RM, Chowdhury P, Fernandez KC, Kim Y, Cols M, Alread W, Yen WF, Hu W, Wang ZM, Violante S, Chaligné R, Li MO, Cross JR, Chaudhuri J.   +14 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Inflammation and B cell activation define a plasma proteome signature predicting tuberculosis in people with HIV. [PDF]

mBio
Kusejko K, Arefian M, Duroux D, Zeeb M, Dollé C, Hoffmann M, Labhardt N, Wandeler G, Cavassini M, Haller S, Bernasconi E, Russenberger D, Kouyos RD, Günthard HF, Collins BC, Nemeth J, Swiss HIV Cohort Study.   +16 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source