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Current Opinion in Immunology, 1995
The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B cells.
J Y, Bonnefoy +4 more
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The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B cells.
J Y, Bonnefoy +4 more
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B‐Cell Activating Properties of Polymyxin B
Scandinavian Journal of Immunology, 1978Polymyxins are known to be inhibitors of certain polyclonal B cell activators such as lipopolysac‐charide and dextransulphate. However, increased specific responses to hapten‐coupled mitogens have been reported after the addition of polymyxins to superoptimal conjugate doses.
C I, Smith, L, Hammarström
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Fueling the fire of B cell activation
Science Immunology, 2023Antigen activated naïve B cells undergoing germinal center responses have distinct metabolic requirements.
Patricia M. Sikorski, Linda L. Kusner
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B Cell Activation and Apoptosis
1995The antigen recognition potential of lymphocytes is theoretically so vast that, without appropriate regulation, the immune system should inevitably react to self-antigens. The development of B and T lymphocytes is therefore controlled at multiple levels in order to ensure that individuals will be able to respond to a large array of foreign antigens ...
P, Sarthou, L, Benhamou, P A, Cazenave
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Current Opinion in Immunology, 1992
Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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T-cell-mediated activation of B cells
Current Opinion in Immunology, 1991Antibody responses to protein antigens are dependent on helper T lymphocytes, which provide necessary growth and differentiation, inducing stimuli to antigen-specific B cells. Recent investigations have focused on the mechanisms of T-B interactions, and the nature of the T-cell-derived signals that are needed for activation and expansion of B cells.
H J, Burstein, A K, Abbas
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Silencing and activating anergic B cells*
Immunological Reviews, 2021AbstractDespite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminate self‐reactive B cells, moderately self‐reactive cells still survive in the periphery (about 20% of peripheral B cells). These cells normally exist in a functionally silenced state called anergy; thus, anergy has been thought to ...
Shinya Tanaka +3 more
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T Cell‐Dependent B Cell Activation
Immunological Reviews, 1984T cell-dependent induction of small, resting B lymphocytes requires direct recognition of antigen and/or I-A/E molecules on the B cell surface by the inducing helper cell, and it does not require the participation of Ig receptors on the responding B cell.
A, Coutinho +7 more
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T Cell\-Dependent B Cell Activation
Annual Review of Immunology, 1993B cells obtain help from T cells in the antibody response by acting as antigen-specific antigen presenting cells. A direct signal through binding of antigen to membrane Ig can enhance B cell antigen presentation and T-dependent B cell activation, but is not required for a productive interaction between a small resting B cell and a differentiated helper
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