Results 211 to 220 of about 2,179,011 (259)

B Cell Activation

1987
The term “B cell activation” describes processes by which small resting B cells, in G0 phase, are stimulated to divide and produce large amounts of secretory Ig molecules. If they are not activated, virgin B cells have a short life and memory B cells remain dormant.
Ian J. Forbes, Anthony S-Y. Leong
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Studies on B-cell activation in vitro

Annales de l'Institut Pasteur / Immunologie, 1983
When antigen activates B cells with the help of T cells, factors are produced by T cells which induce proliferation and maturation to Ig-secreting cells. T-cell lines and T-cell hybridomas have been obtained which, upon stimulation by antigen or by concanavalin A, produce these B-cell replication and maturation factors.
F, Melchers, C, Corbel
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B cell activation in multiple sclerosis

Acta Neurologica Scandinavica, 1986
A microtechnique was established for the study of the limited numbers of cells available in CSF. The method allowed for the determination of the number of immunoglobulin-secreting cells (IgSC) as well as the quantitation of immunoglobulin or specific antibody secreted into the culture medium.
M, Sandberg, A I, Levinson, B, Zweiman, R P, Lisak   +3 more
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Sites of B-cell activation in vivo

Current Opinion in Immunology, 1993
Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites ...
G, Kelsoe, B, Zheng
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Cbl-b in T-cell activation

Seminars in Immunopathology, 2010
Peripheral activation of antigen-specific T cells is stringently controlled to prevent immune responses against self-antigens. Only after a T cell is presented with two signals, an antigen and a co-stimulatory signal, can they be fully activated. In case antigen presentation occurs without co-stimulation, T-cell receptor (TCR) signaling pathways are ...
Magdalena, Paolino, Josef M, Penninger
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Activation of B lymphocytes by NK cells

International Immunology, 1992
The ability of NK cells to induce differentiation of B lymphocytes to IgM secretion in vitro has been investigated. Homogeneous preparations of NK cells obtained from IL-2 propagated splenocytes from SCID mice were found to have the ability to induce resting B lymphocytes to proliferate and secrete significant amounts of IgM.
D, Yuan, J, Wilder, T, Dang, M, Bennett, V, Kumar   +4 more
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Polyclonal B‐cell activation in periodontitis*

Journal of Periodontal Research, 1989
The evidence that periodontitis-associated bacteria contain potent PBA factors is very strong. Clearly, antibodies directed against non-oral antigens are produced in the inflamed periodontal lesion, and PBA appears to contribute to that production.
J, Tew, D, Engel, D, Mangan
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B cell activation

1996
Abstract B lymphocytes are the precursors of antibody-forming cells (AFC), which express clonally distributed surface immunoglobulin (slg) receptors for antigen (generally slgM and slgD). B cells are generated in the bone marrow throughout adult life: this process involves an ordered sequence of gene rearrangements which gener ates a ...
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Early Events in B Cell Activation

Annual Review of Immunology, 2010
B cell activation is initiated by the ligation of the B cell receptor (BCR) with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here we review recent literature concerned with the spatiotemporal dynamic characterization of the early molecular events of B cell activation, including the ...
Naomi E, Harwood, Facundo D, Batista
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Complement activation by a B cell superantigen

The Journal of Immunology, 1996
Abstract Staphylococcal protein A (SpA), acting as a B cell superantigen, binds to the Fab region of human VH3+ Igs. Using SpA abrogated of its IgG Fc binding activity (Mod SpA) as a model B cell superantigen, we determined whether such an interaction causes complement activation.
L M, Kozlowski, A M, Soulika, G J, Silverman, J D, Lambris, A I, Levinson   +4 more
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