Results 121 to 130 of about 1,897,024 (307)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pre-processed B cell receptor repertoire sequencing data from BioProject PRJNA527941

, 2019
Marie Ghraichy, Johannes Trück
openalex   +1 more source

P1151: BENDAMUSTINE-CONTAINING REGIMENS CAN BE SAFELY USED AS BRIDGING IN LARGE B-CELL LYMPHOMA PATIENTS RECEIVING CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY

, 2023
Gloria Garcı́a-Calvo, Vı́ctor Navarro, Ana África Martín López, Mariana Bastos‐Oreiro, Kai Rejeski, Katarzyna Aleksandra Jalowiec, Paula Amat, Juan Luis Reguera Ortega, Viktoria Blumenberg, Laura Gallur, María Herrero, Claire Roddie, Rebeca Bailén, Ana Benzaquén, Cecilia Carmen Carpio Segura, Lucía López‐Corral, Rafael Hernani, Mi Kwon, Lourdes Martín‐Martín, Marion Subklewe, Maeve O’Reilly, Pere Barba   +21 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prognostic value of early post-treatment 18F-FDG PET/CT in diffuse large B-cell lymphoma patients receiving chimeric antigen receptor T-cell therapy [PDF]

Seyed Ali Mirshahvalad, Andrés Kohan, Roshini Kulanthaivelu, Claudia Ortega, Ur Metser, David Hodgson, Robert Kridel, Christine Chen, Sita Bhella, K. Chin, Patrick Veit‐Haibach   +10 more
openalex   +1 more source

B-cell receptor profiling before and after IVIG monotherapy in newly diagnosed idiopathic inflammatory myopathies [PDF]

, 2022
Dornatien C. Anang, H. Walter, Johan Lim, Ilse T. G. Niewold, Linda van der Weele, Eleonora Aronica, Filip Eftimov, Joost Raaphorst, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Anneke J. van der Kooi, Niek de Vries   +11 more
openalex   +1 more source

Terminating B cell receptor signaling

Oncotarget, 2017
Mohammad, Dara K., Nore, Beston F., Smith, C. I. Edvard   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Requirement for CB1 but not GABA_B receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells

, 2010
Sang‐Hun Lee, Iván Soltész
openalex   +2 more sources

Specific detection of non‐functional human P2X₇ receptors in HEK293 cells and B‐lymphocytes [PDF]

, 2003
Julian A. Barden, Ronald Sluyter, Ben J. Gu, James S. Wiley   +3 more
openalex   +1 more source