Results 141 to 150 of about 1,968,688 (264)

Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia. [PDF]

Leukemia
Fascì A, Vallone FE, Nabelsi N, Viry E, Sana I, Morabito A, Seghezzi S, Pesce NA, Rovere M, Bertola N, Duculty C, Ravera S, Mouhssine S, Muzio M, Ghia P, Vitale C, Coscia M, Moussay E, Gaidano G, Allan J, Furman RR, Paggetti J, Vaisitti T, Deaglio S.   +23 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Altered PTPN13-β-catenin interaction by pathogenic mutations and involvement of this axis in B-cell receptor signalling. [PDF]

Sci Rep
Cabrera-Riofrío DA, Li H, García-Calvo C, Sánchez-Bernal C, Sánchez-Yagüe J, Dror Y, Buey RM, Hernández-Hernández Á.   +7 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes. [PDF]

Signal Transduct Target Ther
Zhang Z, Xiang N, Liu Q, Li Y, Wang L, Yang X, Liu J, Zhang L, Lu L, Liang Y, Yang L, Qi X, Liu C.   +12 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Tomato B cell receptor-associated protein 31 homologs enhance thermotolerance by promoting chloroplast PSBW accumulation and stabilizing the PSII-LHCII complex. [PDF]

Plant Commun
Chen C, Xiong F, Hu Y, Qi Z, Wang Y, Ma X, Lv W, Ma N, Meng Q, Lu C, Zhuang K.   +10 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The B cell receptor-mTOR signaling axis restricts the accumulation of lung tissue-resident memory B cells after influenza infection. [PDF]

Sci Immunol
Anupam K, Patel K, Andhare P, Henry B, Hanson CH, Pérez-Pérez L, Kendall PL, Laidlaw BJ.   +7 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source