Results 161 to 170 of about 1,968,688 (264)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in diffuse large B cell lymphoma (DLBCL). [PDF]

Cell Death Dis
Górniak P, Polak A, Rams A, Kupcova K, Głodkowska-Mrówka E, Pilch Z, Miączyńska M, Nowis D, Gołąb J, Davis RE, Havranek O, Juszczyński P.   +11 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus. [PDF]

PLoS Pathog
Huang S, Wu S, Li F, Li P, Sun P, Cao Y, Bao H, Dong K, Yang J, Zhang H, Zhao Q, Sun Y, Li D, Bai X, Fu Y, Yuan H, Ma X, Zhao Z, Zhang J, Wang J, Liu Z, Peng Y, Li K, Hua J, Lu Z, Lei D, Zhang Q.   +26 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Profiling of porcine B-cell receptor heavy-chain repertoires indicates the development of a wide public pseudorabies virus-specific immune response after vaccination and challenge. [PDF]

Discov Immunol
Herbet V, Hirchaud E, Blanchard Y, Beven V, Tranchevent LC, Jarman M, Mittal B, Deblanc C, Paboeuf F, Hammond JA, Eterradossi N, Dory D, Bonnet-Di Placido M.   +12 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Evaluation of the Role of AID-Induced Mutagenesis in Resistance to B-Cell Receptor Pathway Inhibitors in Chronic Lymphocytic Leukemia. [PDF]

Curr Issues Mol Biol
Pighi C, Gasparetto A, Genuardi E, Tao J, Wang Q, Vitale C, Griggio V, Piazza R, Ciavarella S, Coscia M, Ferrero S, Zamò A, Voena C, Chiarle R.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9. [PDF]

J Clin Invest
Guo R, Sun Y, Lim MY, Shah H, Paulo JA, Ahmed RA, Li W, Zhang Y, Yang H, Wang LW, Strebinger D, Smith NA, Li M, Leong MML, Lutchenkov M, Liang JH, Li Z, Wang Y, Puri R, Melnick A, Green MR, Asara JM, Papathanassiu AE, Wesemann DR, Gygi SP, Mootha VK, Gewurz BE.   +26 more
europepmc   +1 more source