Results 181 to 190 of about 2,912,674 (304)

Thrifty wide-context models of B cell receptor somatic hypermutation. [PDF]

Elife
Sung K, Johnson MM, Dumm W, Simon N, Haddox H, Fukuyama J, Matsen FA.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Distinct B cell receptor functions are determined by phosphorylation. [PDF]

PLoS Biology, 2006
Richard Robinson
doaj   +1 more source

Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus. [PDF]

PLoS Pathog
Huang S, Wu S, Li F, Li P, Sun P, Cao Y, Bao H, Dong K, Yang J, Zhang H, Zhao Q, Sun Y, Li D, Bai X, Fu Y, Yuan H, Ma X, Zhao Z, Zhang J, Wang J, Liu Z, Peng Y, Li K, Hua J, Lu Z, Lei D, Zhang Q.   +26 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of the Role of AID-Induced Mutagenesis in Resistance to B-Cell Receptor Pathway Inhibitors in Chronic Lymphocytic Leukemia. [PDF]

Curr Issues Mol Biol
Pighi C, Gasparetto A, Genuardi E, Tao J, Wang Q, Vitale C, Griggio V, Piazza R, Ciavarella S, Coscia M, Ferrero S, Zamò A, Voena C, Chiarle R.   +13 more
europepmc   +1 more source

B-Cell Receptor Binding [PDF]

, 2020
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9. [PDF]

J Clin Invest
Guo R, Sun Y, Lim MY, Shah H, Paulo JA, Ahmed RA, Li W, Zhang Y, Yang H, Wang LW, Strebinger D, Smith NA, Li M, Leong MML, Lutchenkov M, Liang JH, Li Z, Wang Y, Puri R, Melnick A, Green MR, Asara JM, Papathanassiu AE, Wesemann DR, Gygi SP, Mootha VK, Gewurz BE.   +26 more
europepmc   +1 more source