Results 61 to 70 of about 2,912,674 (304)

NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. [PDF]

, 1995
NKR-P1A is a lectinlike surface molecule expressed on rat natural killer (NK) cells. NKR-P1A has structural and functional features of an activating NK cell receptor, but a requirement for NKR-P1A in target cell lysis has not been determined.
Nakamura, MC, Niemi, EC, Ryan, JC, Seaman, WE   +3 more
core  

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

A Bayesian phylogenetic hidden Markov model for B cell receptor sequence analysis. [PDF]

, 2019
The human body generates a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens.
Dhar, Amrit, Matsen, Frederick A, Minin, Vladimir N, Ralph, Duncan K   +3 more
core   +4 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia

Haematologica, 2014
Chronic lymphocytic leukemia B cells express auto/xeno antigen-reactive antibodies that bind to self-epitopes and resemble natural IgM antibodies in their repertoire.
Ann-Charlotte Bergh, Chamilly Evaldsson, Lone Bredo Pedersen, Christian Geisler, Kostas Stamatopoulos, Richard Rosenquist, Anders Rosén   +6 more
doaj   +1 more source

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation [PDF]

, 2016
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B cell receptor (BCR) activation ...
Carr, Steven A, Chandler, Kevin B., Costello, Catherine E., Kanekiyo, Masaru, Lingwood, Daniel, Mascola, John R., McDermott, Adrian B., McTamney, Patrick. M., Nabel, Gary J., Patel, Jinal, Villar, Rina F., Weaver, Grant C., Wheatley, Adam K., Yassine, Hadi M.   +13 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells

iScience, 2019
Summary: Vaccination approaches have generally focused on the antigen rather than the resultant antibodies generated, which differ greatly in quality and function between individuals.
Vera Greiner, Regina Bou Puerto, Suying Liu, Christoph Herbel, Ellese M. Carmona, Michael S. Goldberg   +5 more
doaj   +1 more source

Predicting B Cell Receptor Substitution Profiles Using Public Repertoire Data

, 2018
B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells sharing the same ancestor (i.e.
Davidsen, Kristian, Dhar, Amrit, Matsen IV, Frederick A., Minin, Vladimir N.   +3 more
core   +2 more sources

Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma [PDF]

, 2012
Background: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure.
Benz, Alexander, Christoph, Renné, Hansmann, Martin L.   +2 more
core   +2 more sources