Results 51 to 60 of about 2,912,674 (304)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Advancements in understanding the regulatory mechanism of B-cell immune activation associated with adenotonsillar hypertrophy

生物医学转化
B cells play a crucial role in recognizing external antigens through their surface B cell receptor (BCR), essential for generating protective antibodies and immune memory.
Chen Wenjing, Gao Ruiyu, Huang Jingwen, Ye Jingying, Liu Wanli   +4 more
doaj   +1 more source

The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. [PDF]

, 2015
The orphan Gα13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R   +2 more
core  

Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. [PDF]

, 2010
The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival.
Daniels, TR, Morgan, R, Neacato, II, Pandha, HS, Penichet, ML, Rodríguez, JA   +5 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Active learning for improving out-of-distribution lab-in-the-loop experimental designAll code and data is available at

ImmunoInformatics
The accurate prediction of antibody-antigen binding is crucial for developing antibody-based therapeutics and advancing immunological research. Library-on-library approaches, where many antigens are probed against many antibodies, can identify specific ...
Daria Balashova, Robert Frank, Svetlana Kuzyakina, Dominique Weltevreden, Philippe A. Robert, Geir Kjetil Sandve, Victor Greiff   +6 more
doaj   +1 more source

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. [PDF]

, 1989
Complement receptor type 2 (CR2;CD21), a member of the superfamily of proteins containing short consensus repeats (SCRs), is the B cell receptor for both the gp350/220 envelope protein of Epstein-Barr virus (EBV), and for the C3dg protein of complement ...
Ahearn, JM, Carter, RH, Fearon, DT, Klickstein, LB, Lowell, CA, Mitchell, JA   +5 more
core  

Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. [PDF]

, 2020
Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal effector proteins.
Becker, S., Bhatt, A., Engelke, M., Erdmann, P., Griesinger, C., Hou, Z., Maier, J., Pirkuliyeva, S., Plitzko, J., Wienands, J., Wong, L.   +10 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation

Frontiers in Immunology, 2019
B-cell activation plays a crucial part in the immune system and is initiated via interaction between the B cell receptor (BCR) and specific antigens.
Jingwen Li, Wei Yin, Yukai Jing, Danqing Kang, Lu Yang, Jiali Cheng, Ze Yu, Zican Peng, Xingbo Li, Yue Wen, Xizi Sun, Boxu Ren, Boxu Ren, Chaohong Liu   +13 more
doaj   +1 more source