Results 51 to 60 of about 16,986,655 (207)

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells

iScience, 2019
Summary: Vaccination approaches have generally focused on the antigen rather than the resultant antibodies generated, which differ greatly in quality and function between individuals.
Vera Greiner, Regina Bou Puerto, Suying Liu, Christoph Herbel, Ellese M. Carmona, Michael S. Goldberg   +5 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis

Frontiers in Immunology
BackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du, Yunyun Deng, Ling Deng, Boping Du, Aiying Xing, Hong Tao, Hua Li, Li Xie, Xinyong Zhang, Tao Sun, Tao Sun, Hao Li, Hao Li   +12 more
doaj   +1 more source

Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia

Haematologica, 2014
Chronic lymphocytic leukemia B cells express auto/xeno antigen-reactive antibodies that bind to self-epitopes and resemble natural IgM antibodies in their repertoire.
Ann-Charlotte Bergh, Chamilly Evaldsson, Lone Bredo Pedersen, Christian Geisler, Kostas Stamatopoulos, Richard Rosenquist, Anders Rosén   +6 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]

, 2010
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Mehrabi, M, Brzostek, Joanna, Nigel J Burroughs, Stephane Oddos, Nigel J. Burroughs, Harrison, A, Van der Merwe, Philip Anton, Eissmann, P, Miloserdov, V, Maryam Mehrabi, Daniel M Davis, Koehler, Karsten, Daniel M. Davis, Gould, K, Alice Harrison, Köhler, K, Harrison Alice, Eissmann, Philipp, Oddos, S, Shiqiu Xiong, Davis, Daniel M., Köhler Karsten, Xiong, S, Burroughs, NJ, Köhler, Karsten, Cordoba, Shaun-Paul, Philipp Eissmann, Oddos, Stephane, Xiong, Shiqiu, Miloserdov, Vladimir, Gould Keith, Philip Anton van der Merwe, Davis, DM, Mehrabi, Maryam, Xiong Shiqiu, Cordoba, SP, Burroughs, Nigel J, Davis Daniel M., Miloserdov Vladimir, van der Merwe, PA, Brzostek, J, van der Merwe Philip Anton, Mehrabi Maryam, Karsten Köhler, Burroughs Nigel J., Harrison, Alice, Joanna Brzostek, Cordoba, Shaun Paul, Oddos Stephane, van der Merwe, Philip, Shaun-Paul Cordoba, Burroughs, Nigel J., Cordoba Shaun-Paul, Davis, Daniel M, Burroughs, Nigel John, Gould, Keith, Keith Gould, Vladimir Miloserdov, Eissmann Philipp, Brzostek Joanna   +59 more
core   +1 more source

Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development

Frontiers in Immunology
Chicken B cell development represents a remarkable evolutionary divergence from mammalian paradigms, featuring unique three-stage ontogeny centered on the bursa of Fabricius, an avian-specific primary B cell lymphoid organ.
Seung Je Woo, Thirubasyini Songodan, Jae Yong Han   +2 more
doaj   +1 more source

SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

Haematologica, 2016
I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this disease.
Nili Dezorella, Ben-Zion Katz, Mika Shapiro, Aaron Polliack, Chava Perry, Yair Herishanu   +5 more
doaj   +1 more source