Results 21 to 30 of about 7,553,399 (243)
Atypical chemokine receptor 4 shapes activated B cell fate [PDF]
, 2018 Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed +20 more
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T-cells and B-cells in osteoporosis [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2014 Bone disease is a leading cause of fractures and continues to be a source of significant morbidity and mortality worldwide. As the underlying mechanisms of osteoporosis are elucidated, immune dysfunction continues to emerge as a key precipitating factor in multiple bone disease contexts. This review examines recent findings in the osteoimmunology field
openaire +3 more sources
MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [PDF]
, 2016 MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with ...
Alivernini, Stefano +13 more
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Immunology Today, 1982 The influenza virus behaves unpredictably and can cause devastating pandemics. Nearly 50 years after its first isolation it is probably the most infectious agent known that we cannot yet control. Why? The answer lies in the virus's unique capacity to alter antigenically and in the inability of the host's immune system to respond satisfactorily to the ...
Mcmichael, A +3 more
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The re-emergence of the B1 cell compartment : is this a pre-lymphoma stage? [PDF]
, 2016 Chronic Lymphocytic Leukemia (CLL) are in some cases stereotyped for immunoglobulin variants in different populations, suggesting emergence of B cell subsets following presentation of the same antigen.
Baldacchino, Shawn +4 more
core +1 more source
Elevated myc expression and c-myc amplification in spontaneously occurring B lymphoid cell lines [PDF]
, 1987 Recently, a minor subpopulation of murine B lymphocytes, Ly-1+ B cells, has been distinguished by its unique ontogeny, tissue distribution, and prominence in certain autoimmune and neoplastic B cell diseases.
Baltimore, David +2 more
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Targeting lentiviral vectors to antigen-specific immunoglobulins [PDF]
, 2008 Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases.
Black M.E. +17 more
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The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]
European Journal of Immunology, 2000 B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
Antonius Rolink +3 more
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Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]
, 2008 The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Brune, Verena +12 more
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Transplantation, 2006 Autoreactive B cells are actively tolerized to more abundant self-antigens by a series of checkpoints involving receptor editing, deletion, anergy and competition for growth factors. In contrast, B cells reactive against rare, sequestered or tissue specific self-antigens remain functionally naïve.
Ferry, H +6 more
openaire +3 more sources