Results 21 to 30 of about 29,942,317 (406)

B Cells in Rheumatoid Arthritis：Pathogenic Mechanisms and Treatment Prospects

Frontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its clinical features are the proliferation of joint synovial tissue, the formation of pannus and the destruction of cartilage.
Fengping Wu, Jinfang Gao, Jingmin Kang, Xuexue Wang, Q. Niu, Jiaxi Liu, Liyun Zhang   +6 more
semanticscholar   +1 more source

Systemic Sclerosis and Atherosclerosis: Potential Cellular Biomarkers and Mechanisms

Frontiers in Bioscience-Scholar, 2023
Systemic sclerosis (SSc) is a rare systemic autoimmune disease of unknown etiology, which is characterized by endothelial dysfunction, pathologic vasculopathy, and increased tissue fibrosis. Traditionally, SSc has been regarded as a prototypical fibrotic
Elena V. Gerasimova, Rushana U. Shayakhmetova, Daria A. Gerasimova, Tatiana V. Popkova, Lidia P. Ananyeva   +4 more
doaj   +1 more source

B cell-mediated Immunity against Tuberculosis Infection: A Mini Review Study [PDF]

Reviews in Clinical Medicine, 2020
Mycobacterium tuberculosis (Mtb) is considered to be a major public health concern and a successful intracellular pathogen associated with high mortality worldwide.
Mohsen Karbalaei, Saman Soleimanpour, Majid Eslami, Bahman Yousefi, Masoud Keikha   +4 more
doaj   +1 more source

Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]

The Journal of Immunology, 2007
Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G, Tangye, Kim L, Good
openaire   +2 more sources

B cells are associated with survival and immunotherapy response in sarcoma

Nature, 2020
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation of patients with different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade ...
F. Petitprez, A. Reyniès, E. Keung, T. Chen, Cheng-Ming Sun, J. Calderaro, Y. Jeng, Li-Ping Hsiao, L. Lacroix, A. Bougoüin, M. Moreira, Guillaume Lacroix, Ivo Natario, J. Adam, C. Lucchesi, Y. Laizet, M. Toulmonde, M. Burgess, V. Bolejack, D. Reinke, K. Wani, Wei-Lien Wang, A. Lazar, C. Roland, J. Wargo, A. Italiano, C. Sautès-Fridman, H. Tawbi, W. Fridman   +28 more
semanticscholar   +1 more source

Regulatory B cells, A to Z

Allergy. European Journal of Allergy and Clinical Immunology, 2021
B cells play a central role in the immune system through the production of antibodies. During the past two decades, it has become increasingly clear that B cells also have the capacity to regulate immune responses through mechanisms that extend beyond ...
Kirstin Jansen, Lacin Cevhertas, Siyuan Ma, P. Satitsuksanoa, M. Akdiş, W. van de Veen   +5 more
semanticscholar   +1 more source

B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production. [PDF]

, 2016
A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM.
Alugupalli, Alugupalli, Ansel, Avrech, Barber, Baumgarth, Baumgarth, Baumgarth, Baumgarth, Ben-Hur, Berland, Boes, Boes, Briles, Cazac, Chace, Chen, Choi, Choi, Cole, Colombo, Cosenza, Cunningham, Dexter, Duber, Ehrenstein, Elvington, Flajnik, Forster, Fung, Gil-Cruz, Godin, Gordon, Ha, Haas, Hardy, Hardy, Hayakawa, Hayakawa, Holodick, Holodick, Holodick, Hooijkaas, Kantor, Kantor, Kawahara, Kearney, Kin, Kobayashi, Kretschmer, Kroese, Kroese, Lalor, Lalor, Lalor, Mercolino, Montecino-Rodriguez, Montecino-Rodriguez, Moon, Morris, Murakami, Nguyen, Nisitani, Ohdan, Okabe, Ouchida, Patel, Perdiguero, Rahyab, Reynolds, Sigal, Stoermann, Tominaga, Tornberg, van der Pol, Vas, Vaux, Waffarn, Wardemann, Watanabe, Yang, Yang, Yoshida, Yoshimoto, Yuan, Zhou   +85 more
core   +6 more sources

Ten-year experience with rituximab for induction and maintenance therapy in patients with ANCA-associated systemic vasculitis

Современная ревматология, 2020
Rituximab (RTM), a monoclonal antibody against CD20+ receptors on the membrane of B-cells, is becoming increasingly important for the induction and maintenance treatment of antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (ANCA ...
T. V. Beketova, E. L. Nasonov
doaj   +1 more source

B Cell Immunosenescence

Annual Review of Cell and Developmental Biology, 2020
Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality.
Daniela, Frasca, Alain, Diaz, Maria, Romero, Denisse, Garcia, Bonnie B, Blomberg   +4 more
openaire   +3 more sources

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source