Results 21 to 30 of about 4,351,772 (298)
From mouse genetics to targeting the Rag GTPase pathway
Molecular & Cellular Oncology, 2021 The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease.
Ana Ortega-Molina, Alejo Efeyan
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B cell-mediated Immunity against Tuberculosis Infection: A Mini Review Study [PDF]
Reviews in Clinical Medicine, 2020 Mycobacterium tuberculosis (Mtb) is considered to be a major public health concern and a successful intracellular pathogen associated with high mortality worldwide.
Mohsen Karbalaei +4 more
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General characteristics of adjuvants and their mechanisms of action (part 2)
Биопрепараты: Профилактика, диагностика, лечение, 2021 One of the major public health challenges today is development of new vaccines and technologies to optimize the vaccination process. There is a growing scientific interest in vaccine adjuvants that enhance vaccine immunogenicity.
N. А. Alpatova +5 more
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Experimental Cell Research, 2017 The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor (HIF). Immune cells function in physiologically complex and varying environments whereby oxygen, pH, nutrients, metabolites and cytokines are continuously fluctuating.
Burrows, N, Maxwell, PH
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Arthritis Research & Therapy, 2009 B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development
Thomas Dörner +2 more
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Unique B cell responses in B cell-dependent and B cell-independent EAE
Autoimmunity, 2011 Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Kamaldeen A. Muili +3 more
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STAR Protocols, 2022 Summary: In this protocol, we describe how to generate 3D culture surrogates of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) bone marrow microenvironments. We detail the use of culturing scaffolds populated with BM stromal cells and tumor
Daniela Belloni +6 more
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Systemic Sclerosis and Atherosclerosis: Potential Cellular Biomarkers and Mechanisms
Frontiers in Bioscience-Scholar, 2023 Systemic sclerosis (SSc) is a rare systemic autoimmune disease of unknown etiology, which is characterized by endothelial dysfunction, pathologic vasculopathy, and increased tissue fibrosis. Traditionally, SSc has been regarded as a prototypical fibrotic
Elena V. Gerasimova +4 more
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T cell–B cell collaboration [PDF]
Nature Reviews Immunology, 2017 Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.
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T-cells and B-cells in osteoporosis [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2014 Bone disease is a leading cause of fractures and continues to be a source of significant morbidity and mortality worldwide. As the underlying mechanisms of osteoporosis are elucidated, immune dysfunction continues to emerge as a key precipitating factor in multiple bone disease contexts. This review examines recent findings in the osteoimmunology field
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