Results 31 to 40 of about 21,803,006 (294)

B cells and autoimmunity [PDF]

Current Opinion in Immunology, 2011
There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B ...
Shiv, Pillai, Hamid, Mattoo, Annaiah, Cariappa   +2 more
openaire   +2 more sources

B cells and atherosclerosis [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
B cells have emerged as important immune cells in cardiovascular disease. Initial studies have suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed light on the subset-dependent effects of B cells.
Prasad, Srikakulapu, Coleen A, McNamara
openaire   +2 more sources

SUPERANTIGENS

Acta Agriculturae Slovenica, 1998
Superantigens are bacterial, viral, retroviral and some naturally occurring proteins that can specifically activate a large proportion of T and/or B cells.
Mojca NARAT
doaj   +1 more source

Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Age-Related Macular Degeneration

Medicines, 2020
Background: Dry age-related macular degeneration (AMD) is one of the leading causes of vision loss in older patients. The macula accumulates drusen with loss of retinal pigment epithelial cells and photoreceptors.
Jeffrey N. Weiss, Steven Levy
doaj   +1 more source

Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation

Endocrine Connections, 2020
B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of au toimmune B-cell expression profiles might enable a better understanding of GD pathogenesis.
Xuechao Jiang, Yonghui Wang, Xiaoying Li, Leqi He, Qian Yang, Wei Wang, Jun Liu, Bingbing Zha   +7 more
doaj   +1 more source

Detection of IL-10 in Murine B Cells: In Vitro and In Vivo Techniques

, 2021
With the ever-increasing understanding of the roles of B cells in immune response and autoimmune pathogenesis, various techniques have been optimized for the detection of IL-10 production in B cells.
Wang, X, Xiang Lin, Lin, X, Lu, L, Xiaohui Wang, Liwei Lu   +5 more
core   +1 more source

Cryoglobulinemia and cryoglobulinemic vasculitis: etiological aspects and pathophysiological associations

Современная ревматология, 2020
The term cryoglobulinemia (CG) is used when detecting serum immunoglobulins that reversibly precipitate and form a gel at a temperature below 37 °C and dissolve when the temperature rises above 37 °C.
I. Yu. Golovach, Ye. D. Yegudina
doaj   +1 more source

Dynamic stimulation promotes functional tissue-like organization of a 3D human lymphoid microenvironment model in vitro

Cell Reports: Methods
Summary: This work focused on generating a three-dimensional (3D) in vitro dynamic model to study chronic lymphocytic leukemia (CLL) cell dissemination, homing, and mechanisms of therapy resistance.
Dafne Barozzi, Fiorella Scagnoli, Federica Barbaglio, Daniela Belloni, Davide Ribezzi, Silvia Farè, Valeria Berno, Riccardo Pinos, Marta Sampietro, Margherita Pauri, Barbara Vergani, Francesco Mantegazza, Paolo Ghia, Cristina Scielzo   +13 more
doaj   +1 more source

DETERMINING REFERENCE RANGES FOR TREC AND KREC ASSAYS IN IMMUNE DEFICIENCY SCREENING OF NEWBORNS IN RUSSIAN FEDERATION

Медицинская иммунология, 2019
In this work, we used a reference population of newborns and sampled dried blood spots on Guthrie cards of 2,739 individual samples to determine the reference intervals for TRECs and KRECs values, in order to diagnose primary immunodeficiency by means of
M. A. Gordukova, I. A. Korsunsky, Yu. V. Chursinova, M. M. Byakhova, I. P. Oscorbin, A. P. Prodeus, M. L. Filipenko   +6 more
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Peripheral blood B cell subsets from patients with various activity of chronic sarcoidosis

Медицинская иммунология, 2020
Sarcoidosis is an inflammatory disease of unknown etiology, characterized by development of necrosis-free epithelioid cell granulomas, resulting in hyperactivation of various cells of the immune system.
N. M. Lazareva, I. V. Kudryavtsev, O. P. Baranova, M. K. Serebriakova, A. A. Bazhanov, T. P. Ses’, M. M. Ilkovich, A. A. Totolian   +7 more
doaj   +1 more source