Results 11 to 20 of about 21,803,006 (294)
B Cells and B Cell Depletion in Autoimmunity and Atherosclerosis [PDF]
LifeAlthough previously B cells had been underestimated in comparison to T cells in their role in autoimmunity, now, their impact is well established. Via secretion of autoantibodies, presentation of autoantigens, regulation of antigen processing and presentation, and release of inflammatory cytokines, B cells can mediate cytotoxicity and lead to organ ...
Jenny Lue Solomon +6 more
openaire +3 more sources
IgM-producing tumors in the BALB/c mouse: a model for B-cell maturation [PDF]
, 1974 Five adjuvant induced BALB/c tumors producing IgM—McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781—were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence,
Citronbaum, R. +7 more
core +7 more sources
Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells [PDF]
Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in pancreatic β-cells is unknown.
Z Zhou (7793243) +29 more
core +6 more sources
Современная ревматология, 2020 Rituximab (RTM), a monoclonal antibody against CD20+ receptors on the membrane of B-cells, is becoming increasingly important for the induction and maintenance treatment of antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (ANCA ...
T. V. Beketova, E. L. Nasonov
doaj +1 more source
Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]
Scandinavian Journal of Immunology, 2005 AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
C D, Milne, Y, Zhang, C J, Paige
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Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]
, 2008 B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Müller, Werner +14 more
core +1 more source
Prevention of arthritis by interleukin 10-producing B cells [PDF]
, 2003 In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C. +7 more
core +1 more source
Conditional immortalization of human B cells by CD40 ligation [PDF]
, 2008 It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C. +27 more
core +1 more source
Cancer Cell, 2021 Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth, their organization in tertiary lymphoid structures, and their association with immunotherapy response.
Engelhard, Victor +6 more
openaire +2 more sources
Th17 effector cells support B bell responses outside of germinal centres [PDF]
, 2012 Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers +39 more
core +1 more source