Results 11 to 20 of about 4,576,202 (266)

Ten-year experience with rituximab for induction and maintenance therapy in patients with ANCA-associated systemic vasculitis

Современная ревматология, 2020
Rituximab (RTM), a monoclonal antibody against CD20+ receptors on the membrane of B-cells, is becoming increasingly important for the induction and maintenance treatment of antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (ANCA ...
T. V. Beketova, E. L. Nasonov
doaj   +1 more source

Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]

Scandinavian Journal of Immunology, 2005
AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
C D, Milne, Y, Zhang, C J, Paige
openaire   +2 more sources

Systemic lupus erythematosus: history and modernity

Научно-практическая ревматология, 2022
Systemic lupus erythematosus (SLE) is a systemic autoimmune rheumatic disease of unknown etiology, characterized by hyperproduction of non-organ-specific autoantibodies to various components of the cell nucleus and the development of immune-inflammatory ...
E. L. Nasonov, S. K. Soloviev, A. V. Arshinov   +2 more
doaj   +1 more source

Inhibition of T cell/B cell interaction by B-CLL cells [PDF]

Leukemia, 1999
The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
C, Kneitz, M, Goller, M, Wilhelm, C, Mehringer, G, Wohlleben, A, Schimpl, H P, Tony   +6 more
openaire   +2 more sources

Cellular composition of the minor salivary gland inflammatory infiltrates as an additional diagnostic criterion for primary Sjogren’s syndrome

Научно-практическая ревматология, 2021
Primary Sjogren’s syndrome (pSS) is one of the most frequent among the connective tissue diseases. Histological examination of the minor salivary gland (MSG) is important diagnostic method.
E. S. Kuvardin, I. N. Grigor’yeva, I. A. Bekhtereva, A. L. Maslyansky, Yu. A. Krivolapov, E. A. Belyakova   +5 more
doaj   +1 more source

Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +3 more sources

The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]

European Journal of Immunology, 2000
B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
R, Ceredig, A G, Rolink, F, Melchers, J, Andersson   +3 more
openaire   +2 more sources

Clinical case of primary immunodeficiency: X-linked agammaglobulinemia

Медицинская иммунология, 2020
Aclinical case ofprimary immunodeficiency state (PIDS) is described: X-linked agammaglobulinemia in the boy of 8 years old. The results of molecular genetic studies: gene btk (ex 1-19) genome version GRCh38.p5, transcript version ENST00000308731 single ...
E. V. Kuvschinova, L. M. Kurtasova, A. G. Borisov, A. R. Schmidt, T. A. Gerasimova   +4 more
doaj   +1 more source

Unique B cell responses in B cell-dependent and B cell-independent EAE

Autoimmunity, 2011
Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Guorong, Liu, Kamaldeen A, Muili, Vrushali V, Agashe, Jeri-Anne, Lyons   +3 more
openaire   +2 more sources

Immunomodulatory Treatment Strategies Targeting B Cells for Heart Failure

Frontiers in Pharmacology, 2022
Cardio-oncology, a nascent specialty, has evolved as a concerted strategy to address the cardiovascular complications of cancer therapies. On the other hand, emerging evidence has shown that some anti-tumor drugs, such as CD20-targeted rotuximab, also ...
Xinxin Zhang, Yuxi Sun, Ning Wang, Yanli Zhang, Yunlong Xia, Ying Liu   +5 more
doaj   +1 more source