Results 11 to 20 of about 5,251,416 (217)
Современная ревматология, 2020 Rituximab (RTM), a monoclonal antibody against CD20+ receptors on the membrane of B-cells, is becoming increasingly important for the induction and maintenance treatment of antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (ANCA ...
T. V. Beketova, E. L. Nasonov
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Conditional immortalization of human B cells by CD40 ligation [PDF]
, 2008 It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C. +27 more
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Th17 effector cells support B bell responses outside of germinal centres [PDF]
, 2012 Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers +39 more
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Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]
Scandinavian Journal of Immunology, 2005 AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
C D, Milne, Y, Zhang, C J, Paige
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Prevention of arthritis by interleukin 10-producing B cells [PDF]
, 2003 In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C. +7 more
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Systemic lupus erythematosus: history and modernity
Научно-практическая ревматология, 2022 Systemic lupus erythematosus (SLE) is a systemic autoimmune rheumatic disease of unknown etiology, characterized by hyperproduction of non-organ-specific autoantibodies to various components of the cell nucleus and the development of immune-inflammatory ...
E. L. Nasonov +2 more
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Inhibition of T cell/B cell interaction by B-CLL cells [PDF]
Leukemia, 1999 The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
C, Kneitz +6 more
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Научно-практическая ревматология, 2021 Primary Sjogren’s syndrome (pSS) is one of the most frequent among the connective tissue diseases. Histological examination of the minor salivary gland (MSG) is important diagnostic method.
E. S. Kuvardin +5 more
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Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]
, 2008 B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Müller, Werner +14 more
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Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]
Journal of Internal Medicine, 2017 AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman +5 more
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