Results 51 to 60 of about 5,251,416 (217)

B cells in autoimmunity

Proceedings of the National Academy of Sciences, 2000
Interest is reviving in the role of antibodies in autoimmunity. Over the last two decades, T cells occupied center stage for several reasons: They predominate within tissues undergoing autoimmune attack, they can transfer autoimmune disease in animal models, and diseases such as rheumatoid arthritis and insulin-dependent diabetes mellitus associate ...
N A, Mitchison, L R, Wedderburn
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CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
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Early growth response gene-2 (Egr-2) regulates the development of B and T cells

, 2011
The study was supported by Arthritis Research UK. Copyright @ 2011 Li et al.BACKGROUND: Understanding of how transcription factors are involved in lymphocyte development still remains a challenge.
Miao, T, Wang Ping, Zhu, B, Zhu Bo, Alistair L. J. Symonds, Symonds, A L J, Mengya Liu, Liu, M, Liu, MY, Raymond, MV, Wang, P, Liu Mengya, Symonds, ALJ, Suling Li, Miao Tizong, Li Suling, Alistair L J Symonds, Li, SL, Tizong Miao, Ping Wang, Symonds Alistair L. J., Meera V. Raymond, Meera V Raymond, Raymond, M, Raymond Meera V., Miao, TZ, Li, S, Bo Zhu   +27 more
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Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies

Cancer Biology & Medicine, 2021
Tertiary lymphoid structures (TLSs) are ectopic immune cell aggregations that develop in peripheral tissues in response to a wide range of chronic inflammatory conditions, including infection, autoimmune disease, and cancer. In the tumor microenvironment
Hua Zhao, Hao Wang, Qiuru Zhou, Xiubao Ren   +3 more
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Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints [PDF]

, 2014
We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA).
Harnett, M.M., Al-Riyami, Lamyaa, Pineda, M.A., Harnett, W., Harnett, Margaret M., Lamyaa Al-Riyami, Miguel A. Pineda, Rodgers, David T., Harnett, William, McGrath, M.A., Rodgers, D.T., David T. Rodgers, McGrath, Mairi A., Margaret M. Harnett, Al-Riyami, L., Pineda, Miguel A., Mairi A. McGrath, William Harnett   +17 more
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The B cell antigen receptor in B-cell development

Current Opinion in Immunology, 1994
During B-cell development, immature and mature forms of the B cell antigen receptor complex are deployed in a regulated fashion; thus, B cell antigen receptor complexes play essential roles in the transit of cells through ontogeny. The past year has seen progress in our understanding of how antigen receptor gene assembly is controlled and in defining ...
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The V_H gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]

, 2003
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI, Gary Rowley, Fraser, N.L.W., Field, M, Fraser, NLW, Rowley, G., Field, M., Max Field, Rowley, G, David I Stott, Stott, D.I., Nicola LW Fraser   +11 more
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Absolute Counts of Peripheral Lymphocyte Subsets Correlate with the Progression-Free Survival and Metastatic Status of Pancreatic Neuroendocrine Tumour Patients

Cancer Management and Research, 2020
Yitao Gong,1– 4,* Zhiyao Fan,1– 4,* Guopei Luo,1– 4,* Qiuyi Huang,1– 4 Yunzhen Qian,1– 4 He Cheng,1– 4 Kaizhou Jin,1– 4 Quanxing Ni,1– 4 Xianjun Yu,1– 4 Chen Liu1– 4 1Department of Pancreatic ...
Gong Y, Fan Z, Luo G, Huang Q, Qian Y, Cheng H, Jin K, Ni Q, Yu X, Liu C   +9 more
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Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn, Bushell, A, Hester, J, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Wood, KJ, Hester, Joanna   +9 more
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B Cell Activation

Immunological Reviews, 1975
SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
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