Results 61 to 70 of about 5,251,416 (217)

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Functional characteristics of the gene promoters of anti-inflammatory cytokines TGF-b and IL-10 in B lymphocyte cell models

Медицинская иммунология
B cells play a crucial role in the pathogenesis of various diseases, such as autoimmune disorders, cancers, and infections. Unlike regulatory T cells, the anti-inflammatory capabilities of B cells have only recently garnered attention.
A. N. Uvarova, A. S. Ustiugova, E. A. Zheremyan, E. M. Stasevich, K. V. Korneev, D. V. Kuprash   +5 more
doaj   +1 more source

Human hematopoietic stem/progenitor cells generate CD5⁺ B lymphoid cells in NOD/SCID mice

, 1999
The nonobese diabetic/severe combined immunodeficient (NOD/SCID) xenotransplantation model is increasingly utilized to study both human lymphohematopoietic stem/progenitor cells and committed cell types.
Ramírez, Manuel, Civin, Curt I., Novelli, Enrico M., Leung, Wing   +3 more
core   +1 more source

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Ghaffari, Emma, Liu, Mengya, Liu, M, Wang, Ping, Miao, Tizong, Li, Suling, Wang, P, Sebastian, M, Ghaffari, E, Sebastian, Meera, Symonds, Alistair L.J., Li, S, Symonds, ALJ, Bhullar, Punamdip   +15 more
core   +1 more source

B cells in transplantation [PDF]

The Journal of Heart and Lung Transplantation, 2016
B cell responses underlie the most vexing immunological barriers to organ transplantation. Much has been learned about the molecular mechanisms of B cell responses to antigen and new therapeutic agents that specifically target B cells or suppress their functions are available.
Esme I, Dijke, Jeffrey L, Platt, Paul, Blair, Menna R, Clatworthy, Jignesh K, Patel, A G, Kfoury, Marilia, Cascalho   +6 more
openaire   +2 more sources

Clinical Features and Prognosis of 74 Cases of Lymphoblastic Lymphoma

Zhongliu Fangzhi Yanjiu, 2018
Objective To analyze clinical features of lymphoblastic lymphoma(LBL), compare clinical and prognostic characteristics of B lymphoblasts lymphoma (B-LBL) and T lymphoblasts lymphoma (T-LBL), and the prognosis of various chemotherapy regimens on LBL ...
YUAN Ying, ZANG Li, YUE Zhijie, ZHANG Yizhuo, WANG Xiaofang   +4 more
doaj   +1 more source

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
Axel Walch, Alan G Pockley, Foulds, GA, Pockley, A. G., Foulds, G. A., Doss, B. T., Pockley, AG, Stangl Stefan, Kirschner, A., Foulds, G.A., Gehrmann, M., Multhoff, G., Walch Axel, Doß Brigitte T., Walch, A.K., Kirschner, A, Gehrmann Mathias, Gemma A Foulds, Stangl, S., Walch, A., Doß, B.T., Pockley, A.G., Multhoff, G, Sievert Wolfgang, Stefan Stangl, Stangl, S, Pockley Alan G., Mathias Gehrmann, Multhoff Gabriele, Sievert, W, Sievert, W., Foulds Gemma A., Andreas Kirschner, Kirschner Andreas, Wolfgang Sievert, Gehrmann, M, Gabriele Multhoff, Doß, BT, Brigitte T Doss, Walch, A   +39 more
core   +1 more source

Atypical Mitochondrial Phenotype of Colonic CD4+ and CD8+ T Cells During Experimental Chronic Colitis

Biomedicines
Background: Patients with ulcerative colitis (UC) suffer from a chronic relapsing-remitting inflammatory bowel disease and show heterogeneous disease severity and therapy response.
Jonas Negele, Tobias Franz, Anna Krone, Marc Roder, Elif Gelmez, Nouria Jantz-Naeem, Olivia Kershaw, Verena Keitel-Anselmino, Andreas Jeron, Dunja Bruder, Sascha Kahlfuß   +10 more
doaj   +1 more source

B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

OncoImmunology, 2017
Evidence of tumor-resident mature B cell and antibody compartments and reports of associations with favorable prognosis in malignant melanoma suggest that humoral immunity could participate in antitumor defense.
Giulia Chiaruttini, Silvia Mele, James Opzoomer, Silvia Crescioli, Kristina M. Ilieva, Katie E. Lacy, Sophia N. Karagiannis   +6 more
doaj   +1 more source

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke [PDF]

, 2009
The activation of transcription factor NF-kappaB is controlled by two main pathways: the classical canonical (RelA/p65-p50)- and the alternative noncanonical (RelB/p52)-NF-kappaB pathways.
Edirisinghe, Indika, Sime, Patricia J, Rajendrasozhan, Saravanan, Valvo, Samantha, McCabe Jr., Michael J, Bulger, Michael, Yao, Hongwei, Rahman, Irfan, Yang, Se-Ran, Li, Jian-Dong, Chung, Sangwoon, Fromm, George, Phipps, Richard P   +12 more
core   +1 more source