Results 121 to 130 of about 36,341 (274)

Effects of baclofen on swallow motor pattern

open access: yesFrontiers in Neurology
Baclofen is a GABAB receptor agonist used clinically to manage spasticity. It has also been associated with increased duration of mechanical ventilation and rates of aspiration pneumonitis. We hypothesized that baclofen would impair pharyngeal swallow, a
Nathan W. Fielder   +6 more
doaj   +1 more source

Motion‐Style Scalp Acupuncture Ameliorates Post‐Stroke Muscle Spasticity Through Cerebral Blood Flow Augmentation and 5‐HT2AR‐Mediated Spinal KCC2 Reactivation

open access: yesBrain and Behavior, Volume 15, Issue 12, December 2025.
Pathology of PSS and the antispastic mechanism of MSSA: A focus on cerebral blood flow augmentation and 5‐HT2AR‐mediated KCC2 activation. Abbreviations: CST, corticospinal tract; CRT, corticoreticular tract, RST, reticulospinal tract; rCBF, regional cerebral blood flow; PSS, post‐stroke spasticity. ABSTRACT Background Muscle spasticity, a prevalent and
Qin‐Yong Zhang   +8 more
wiley   +1 more source

Effects of baclofen on insular gain anticipation in alcohol-dependent patients — a randomized, placebo-controlled, pharmaco-fMRI pilot trial [PDF]

open access: hybrid, 2022
Patricia Pelz   +10 more
openalex   +1 more source

Mitochondrial HMG‐CoA Synthase Deficiency Presenting as Pediatric Metabolic Stroke: A Case Report of a Novel Homozygous HMGCS2 (p.Ile56Asn) Variant

open access: yesClinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Mitochondrial HMG‐CoA synthase deficiency should be suspected in infants with hypoketotic hypoglycemia, metabolic acidosis, and basal ganglia lesions. A 2‐year‐old boy with a novel HMGCS2 variant presented with refractory seizures and encephalopathy, highlighting the need for rapid metabolic and genetic evaluation for timely management.
Yasmeen Alshami   +7 more
wiley   +1 more source

Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU

open access: yesData in Brief, 2019
In the intensive care unit, alcohol intake above the NIAAA recommendations regardless of the existence of an Alcohol Use Disorder (AUD), was associated with an increased risk of death and longer time on ventilator.
Mickael Vourc'h   +7 more
doaj   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li   +13 more
wiley   +1 more source

Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series [PDF]

open access: bronze, 2017
Shenandoah Robinson   +5 more
openalex   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

open access: yesMedicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao   +6 more
wiley   +1 more source

THE DYNAMICS OF HISTOMORPHOLOGICAL CHANGES IN ACUTE BACLOFEN POISONING [PDF]

open access: bronze, 2023
Olga Romanova   +3 more
openalex   +1 more source

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