Advanced Science, Volume 13, Issue 13, 3 March 2026.This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen +4 more
wiley +1 more source
eDNA-Amyloid Synergistic Interactions in Bacterial Biofilms: A Hidden Driver of Antimicrobial Resistance. [PDF]
Int J Mol SciGong W, Cheng X, Villena J, Kitazawa H.
europepmc +1 more source
Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides
Advanced Science, Volume 13, Issue 18, 27 March 2026.This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das +13 more
wiley +1 more source
Antimicrobial Peptides as Cross-Seeding Modulators at the Neurodegenerative-Infectious Interface. [PDF]
Research (Wash D C)Zhang Y, Tang Y, Wang L, Zheng J.
europepmc +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Construction of an auxiliary diagnostic model for secondary pulmonary bacterial infection in influenza based on routine detection indicators. [PDF]
Am J Transl ResHe LZ, Huang GC, Bao YF.
europepmc +1 more source
Aerogel Scaffolds: Breathing Life Into Tissue Repair and Companion Diagnostics
Aggregate, Volume 7, Issue 3, March 2026.Aerogel scaffolds are emerging as multifunctional biomedical platforms that bridge regenerative engineering and molecular diagnostics. By integrating hierarchical porosity, tunable mechanics, and programmable surface chemistry, aerogels can simultaneously support tissue reconstruction and enable localized biomarker sampling and signal transduction ...
Hanlin Zhang +5 more
wiley +1 more source
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E. coli. [PDF]
J Biol ChemGurnani B, Jain N.
europepmc +1 more source
The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factors converge on neuromodulatory subcortical systems to confer AD risk or resilience.
Alfie Wearn +4 more
wiley +1 more source