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Functional Bacterial Amyloids in Biofilms
2011Functional bacterial amyloids constitute a group of important proteinaceous surface structures. Most amyloids are highly insoluble in water and resistant to most enzymes and thermal and chemical denaturants. Their functions in bacteria are still not well described but seem to include fimbriae and other cell appendages for adhesion and biofilm formation,
Nielsen, Per Halkjær +4 more
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Amyloid-like Properties of Bacterial Inclusion Bodies
Journal of Molecular Biology, 2005Bacterial inclusion bodies are major bottlenecks in protein production, narrowing the spectrum of relevant polypeptides obtained by recombinant DNA. While regarded as amorphous deposits formed by passive and rather unspecific precipitation of unfolded chains, we prove here that they are instead organized aggregates sharing important structural and ...
Mar, Carrió +4 more
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Molecular architecture of bacterial amyloids in Bacillus biofilms
The FASEB Journal, 2019The formation of biofilms provides structural and adaptive bacterial response to the environment. In Bacillus species, the biofilm extracellular matrix is composed of exopolysaccharides, hydrophobins, and several functional amyloid proteins.
Nadia, El Mammeri +16 more
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The bacterial OMP amyloids modulate α-synuclein and amyloid-β aggregation
International Journal of Biological MacromoleculesGrowing evidence links gut microbiota to neurodegenerative diseases, yet direct molecular interactions between bacterial and host amyloid proteins remain incompletely understood. Bacterial amyloids represent an understudied yet potentially critical component of gut-brain communication in neurodegeneration.
Maksim I, Sulatsky +7 more
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Pathogenesis-Associated Bacterial Amyloids: The Network of Interactions
Biochemistry (Moscow)Amyloids are protein fibrils with a characteristic cross-β structure that is responsible for the unusual resistance of amyloids to various physical and chemical factors, as well as numerous pathogenic and functional consequences of amyloidogenesis. The greatest diversity of functional amyloids was identified in bacteria.
Haidar Fayoud +3 more
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2015
Curli are functional amyloid fibers assembled by many Gram-negative bacteria as part of an extracellular matrix that encapsulates the bacteria within a biofilm. A multicomponent secretion system ensures the safe transport of the aggregation-prone curli subunits across the periplasm and outer membrane, and coordinates subunit self-assembly into surface ...
Van Gerven, Nani +3 more
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Curli are functional amyloid fibers assembled by many Gram-negative bacteria as part of an extracellular matrix that encapsulates the bacteria within a biofilm. A multicomponent secretion system ensures the safe transport of the aggregation-prone curli subunits across the periplasm and outer membrane, and coordinates subunit self-assembly into surface ...
Van Gerven, Nani +3 more
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In Vivo Expression of the Bacterial Amyloid Curli
2016Salmonella enterica serotype Typhimurium is a rod-shaped, motile, Gram-negative bacterium that causes gastroenteritis in immunocompetent individuals. S. Typhimurium produces an extracellular protein termed curli, a bacterial amyloid with a cross beta-sheet tertiary structure that is common across all amyloids.
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