Results 111 to 120 of about 6,595 (270)

Genetic code expansion for chemosensing and chemical actuation of biological functions

Bulletin of the Korean Chemical Society, EarlyView.
Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley   +1 more source

The house that Kocuria built: A potential role for functional amyloid in the unique cube-based structure of K. varians biofilms

The Microbe
Biofilm is the dominant growth mode of microorganisms, providing protection, surface adhesion and synergy between co-habiting organisms. Many aspects of biofilm formation and architecture remain unknown and vary greatly among different species.
Daniel E. Otzen, Gabriel Antonio S. Minero, Henriette L. Røder, Anders M. Torp, Jakob Herschend, Lotte G. Nielsen, Olena Moshynets, Janni Nielsen, Rikke L. Meyer, Morten K.D. Dueholm, Mette Burmølle   +10 more
doaj   +1 more source

Artificial Inclusion Bodies for Clinical Development

Advanced Science, 2020
Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials ...
Julieta M. Sánchez, Hèctor López‐Laguna, Patricia Álamo, Naroa Serna, Alejandro Sánchez‐Chardi, Verónica Nolan, Olivia Cano‐Garrido, Isolda Casanova, Ugutz Unzueta, Esther Vazquez, Ramon Mangues, Antonio Villaverde   +11 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Extracellular host DNA contributes to pathogenic biofilm formation during periodontitis

Frontiers in Cellular and Infection Microbiology
IntroductionPeriodontal diseases are known to be associated with polymicrobial biofilms and inflammasome activation. A deeper understanding of the subgingival cytological (micro) landscape, the role of extracellular DNA (eDNA) during periodontitis, and ...
Mariana Slobodianyk-Kolomoiets, Svitlana Khlebas, Iryna Mazur, Kateryna Rudnieva, Kateryna Rudnieva, Viktoria Potochilova, Olga Iungin, Olga Iungin, Olexandr Kamyshnyi, Iryna Kamyshna, Geert Potters, Geert Potters, Andrew J. Spiers, Olena Moshynets   +13 more
doaj   +1 more source

Neurodegeneration: A Tale of Microbes and Neurons [PDF]

Modern Medicine
The gut-brain axis has emerged as a central paradigm in understanding the bidirectional relationship between the gastrointestinal microbiota and the central nervous system (CNS), particularly within the context of neurodegenerative disorders. This review
Octavian Costin IOGHEN, Mihaela Roxana IOGHEN, Bogdan Ovidiu POPESCU   +2 more
doaj   +1 more source

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation. [PDF]

Int J Mol Sci, 2021
Haikal C, Ortigosa-Pascual L, Najarzadeh Z, Bernfur K, Svanbergsson A, Otzen DE, Linse S, Li JY.   +7 more
europepmc   +1 more source

Natural supramolecular protein assemblies [PDF]

, 2016
Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and ...
Mecinović, Jasmin, Nolte, Roeland J. M., Pieters, Bas J. G. E., van Eldijk, Mark B.   +3 more
core   +2 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source