Results 11 to 20 of about 202,274 (318)
Entry and exit of bacterial outer membrane proteins. [PDF]
Trends Microbiol, 2015 The sites of new outer membrane protein (OMP) deposition and the fate of pre-existing OMPs are still enigmatic despite numerous concerted efforts. Rassam et al. identified mid-cell regions as the primary entry points for new OMP insertion in clusters, driving the pre-existing OMP clusters towards cell poles for long-term storage.
Misra R.
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Selective pressure for rapid membrane integration constrains the sequence of bacterial outer membrane proteins. [PDF]
Mol Microbiol, 2017 SummaryAlmost all bacterial outer membrane proteins (OMPs) contain a β barrel domain that serves as a membrane anchor, but the assembly and quality control of these proteins are poorly understood. Here, we show that the introduction of a single lipid‐facing arginine residue near the middle of the β barrel of the Escherichia coli OMPs OmpLA and EspP ...
Peterson JH +3 more
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Protein-protein interactions and the spatiotemporal dynamics of bacterial outer membrane proteins.
Curr Opin Struct Biol, 2015 It has until recently been unclear whether outer membrane proteins (OMPs) of Gram-negative bacteria are organized or distributed randomly. Studies now suggest promiscuous protein-protein interactions (PPIs) between β-barrel OMPs in Escherichia coli govern their local and global dynamics, engender spatiotemporal patterning of the outer membrane into ...
Kleanthous C, Rassam P, Baumann CG.
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Insertion of proteins and lipopolysaccharide into the bacterial outer membrane [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 The bacterial outer membrane contains phospholipids in the inner leaflet and lipopolysaccharide (LPS) in the outer leaflet. Both proteins and LPS must be frequently inserted into the outer membrane to preserve its integrity. The protein complex that inserts LPS into the outer membrane is called LptDE, and consists of an integral membrane protein, LptD,
Istvan Botos +2 more
semanticscholar +4 more sources
The structure of bacterial outer membrane proteins
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002 Integral membrane proteins come in two types, alpha-helical and beta-barrel proteins. In both types, all hydrogen bonding donors and acceptors of the polypeptide backbone are completely compensated and buried while nonpolar side chains point to the membrane. The alpha-helical type is more abundant and occurs in cytoplasmic (or inner) membranes, whereas
Georg E. Schulz
semanticscholar +6 more sources
Interactions between folding factors and bacterial outer membrane proteins [PDF]
Molecular Microbiology, 2005 SummaryThe outer membrane is the first line of contact between Gram‐negative bacteria and their external environment. Embedded in the outer membrane are integral outer membrane proteins (OMPs) that perform a diverse range of tasks. OMPs are synthesized in the cytoplasm and are translocated across the inner membrane and probably diffuse through the ...
Jesper E. Mogensen, Daniel E. Otzen
semanticscholar +6 more sources
Extraction and Electrophoretic Analysis of Bacterial Lipopolysaccharides and Outer Membrane Proteins
Bio-Protocol, 2021 Lipopolysaccharides (LPS) (or lipooligosaccharides [LOS], which lack the O-antigen side chains characteristic of LPS), and outer membrane proteins (OMP) are major cell-surface molecules in the outer membrane (OM) of gram-negative bacteria.
Yue Lee, Thomas Inzana
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Is the C-terminal insertional signal in Gram-negative bacterial outer membrane proteins species-specific or not? [PDF]
BMC Genomics, 2012 BackgroundIn Gram-negative bacteria, the outer membrane is composed of an asymmetric lipid bilayer of phopspholipids and lipopolysaccharides, and the transmembrane proteins that reside in this membrane are almost exclusively β-barrel proteins.
Nagarajan Paramasivam +2 more
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Exploring bacterial outer membrane barrier to combat bad bugs
Infection and Drug Resistance, 2017 Ishan Ghai,1 Shashank Ghai2 1School of Engineering and Life Sciences, Jacobs University, Bremen, 2Leibniz University, Hannover, Germany Abstract: One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an ...
Ghai I, Ghai S
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Mechanisms of Protein Export across the Bacterial Outer Membrane [PDF]
Journal of Bacteriology, 2005 Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pili and flagella; nutrient acquisition; virulence; and efflux of drugs and other toxins. Export of these proteins to the bacterial surface involves transport across the inner membrane (IM), periplasm, and outer membrane (OM) of the cell ...
Maria Kostakioti +3 more
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