RomA, A Periplasmic Protein Involved in the Synthesis of the Lipopolysaccharide, Tunes Down the Inflammatory Response Triggered by Brucella [PDF]
, 2018 Brucellaceae are stealthy pathogens with the ability to survive and replicate in the host in the context of a strong immune response. This capacity relies on several virulence factors that are able to modulate the immune system and in their structural ...
Altabe, Silvia Graciela +10 more
core +1 more source
Driving Forces for Protein Secretion Across the Bacterial Outer Membrane [PDF]
Biophysical Journal, 2014 Autotransporters are a large and diverse class of monomeric virulence proteins secreted from Gram-negative bacterial pathogens. Secretion across the outer membrane is facilitated by the C-terminal translocator domain that creates a pore in the outer membrane, through which the N-terminal passenger (the functional, extracellular part of the protein ...
Igor Drobnak, Patricia L. Clark
openaire +2 more sources
Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM
Nature Communications, 2021 The β-barrel assembly machinery (BAM) assists the folding and membrane insertion of bacterial outer membrane proteins. Here, the authors report structural characterization of BAM in lipid environment and in complex with the client protein EspP integrated
Runrun Wu +12 more
doaj +1 more source
Domain organization of long autotransporter signal sequences [PDF]
, 2010 Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander +1 more
core +1 more source
Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC. [PDF]
, 2018 Fusobacterium nucleatum is a key member of the human oral biofilm. It is also implicated in preterm birth and colorectal cancer. To facilitate basic studies of fusobacterial virulence, we describe here a versatile transposon mutagenesis procedure and a ...
Abu Amar Mohamed Al Mamun +10 more
core +2 more sources
Isolate Specific Cold Response of Yersinia enterocolitica in Transcriptional, Proteomic, and Membrane Physiological Changes [PDF]
, 2020 Yersinia enterocolitica, a zoonotic foodborne pathogen, is able to withstand low temperatures. This psychrotrophic ability allows it to multiply in food stored in refrigerators. However, little is known about the Y. enterocolitica cold response.
Alter, Thomas +4 more
core +1 more source
mBio, 2015 LytM proteins belong to a family of bacterial metalloproteases. In Gram-negative bacteria, LytM factors are mainly reported to have a direct effect on cell division by influencing cleavage and remodeling of peptidoglycan.
Giuseppe Ercoli +11 more
doaj +1 more source
Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris [PDF]
, 2014 This study investigated the structural and biophysical characteristics of GumB and GumC, two Xanthomonas campestris membrane proteins that are involved in xanthan biosynthesis. Xanthan is an exopolysaccharide that is thought to be a virulence factor that
Bianco, María Isabel +5 more
core +1 more source
Display of Recombinant Proteins on Bacterial Outer Membrane Vesicles by Using Protein Ligation [PDF]
Applied and Environmental Microbiology, 2018 ABSTRACT The Escherichia coli virulence factor hemoglobin protease (Hbp) has been engineered into a surface display system that can be expressed to high density on live E. coli and Salmonella enterica serovar Typhimurium cells or derived outer membrane ...
van den Berg-van Saparoea, H.B. +5 more
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Novel sterol binding domains in bacteria
eLifeSterol lipids are widely present in eukaryotes and play essential roles in signaling and modulating membrane fluidity. Although rare, some bacteria also produce sterols, but their function in bacteria is not known.
Liting Zhai +6 more
doaj +1 more source