Results 71 to 80 of about 358,692 (311)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Domain organization of long autotransporter signal sequences [PDF]

, 2010
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander, Schneider, Gisbert (Prof. Dr.)   +1 more
core   +1 more source

Isolate Specific Cold Response of Yersinia enterocolitica in Transcriptional, Proteomic, and Membrane Physiological Changes [PDF]

, 2020
Yersinia enterocolitica, a zoonotic foodborne pathogen, is able to withstand low temperatures. This psychrotrophic ability allows it to multiply in food stored in refrigerators. However, little is known about the Y. enterocolitica cold response.
Alter, Thomas, Li, Chenyang, Murugaiyan, Jayaseelan, Riedel, Carolin, Thomas, Christian   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analyzing the molecular mechanism of lipoprotein localization in Brucella

Frontiers in Microbiology, 2015
Bacterial lipoproteins possess comprehensive structure and functionality, ranging from bacterial physiology to pathogenic processes. As such many lipoproteins, originating from Brucella are exploited as potential vaccines to countermeasure brucellosis ...
Shivani eGoolab, Shivani eGoolab, Robyn Lindsay Roth, Henriette evan Heerden, Michael Craig Crampton   +4 more
doaj   +1 more source

Comparative proteomics of uropathogenic Escherichia coli during growth in human urine identify UCA-like (UCL) fimbriae as an adherence factor involved in biofilm formation and binding to uroepithelial cells [PDF]

, 2015
Uropathogenic Escherichia coli (UPEC) are the primary cause of urinary tract infection (UTI) in humans. For the successful colonisation of the human urinary tract, UPEC employ a diverse collection of secreted or surface-exposed virulence factors ...
Allsopp, LP, Moriel, DG, Schembri, MA, Totsika, M, Webb, RI, Wurpel, DJ   +5 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation

mBio, 2021
Outer membrane proteins (OMPs) play critical roles in bacterial pathogenicity and provide a new niche for antibiotic development. A comprehensive understanding of the OMP quality control network will strongly impact antimicrobial discovery.
Wei He, Gangjin Yu, Tianpeng Li, Ling Bai, Yuanyuan Yang, Zixiao Xue, Yonghao Pang, Dana Reichmann, Sebastian Hiller, Lichun He, Maili Liu, Shu Quan   +11 more
doaj   +1 more source

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase [PDF]

Journal of Biological Chemistry, 2012
Mitochondria are of bacterial ancestry and have to import most of their proteins from the cytosol. This process is mediated by Tom40 an essential protein that forms the protein translocating pore in the outer mitochondrial membrane. Tom40 is conserved in virtually all eukaryotes but its evolutionary origin is unclear because bacterial orthologues have ...
Harsman Anke, Niemann Moritz, Pusnik Mascha, Schmidt Oliver, Burmann Björn M, Hiller Sebastian, Meisinger Chris, Schneider André, Wagner Richard   +8 more
openaire   +1 more source

The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]

, 2015
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Adam Dyer, Albrecht, Bagos, Barcena-Uribarri, Behera, Bhide, Bordier, Brooks, Bunikis, Cabello, Casjens, Coutte, Crago, Crother, Cullen, Di, Dietrich, Eddy, Eswar, Fairman, Feng, Finn, Fraser, Freeman, Gemma Brown, Gessmann, Greene, Guina, Heffernan, Hong, Jaroszewski, Kenedy, Koebnik, Kopp, Kraiczy, Kurtenbach, Lenhart, Lenka Stejskal, Livengood, Margos, Mertins, Mittal, Nair, Oksi, Ornstein, Ostberg, Paetzel, Pautsch, Petersen, Peter R. Laity, Pettersen, Prasadarao, Preac-Mursic, Pugsley, Pulzova, Richard J. Bingham, Robert, Rogovskyy, Schmidli, Schulz, Setubal, Skare, Sperisen, Steere, Struyve, Sugawara, Svergun, Tamm, Thein, Tilly, Tommassen, Vogt, Volkov, Xie, Yamashita, Yang, Zhang   +76 more
core   +1 more source