Results 61 to 70 of about 308,540 (300)

The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]

, 2019
Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin, Coenye, Tom, Crabbé, Aurélie, Daled, Simon, De Keersmaecker, Herlinde, Deforce, Dieter, Dhaenens, Maarten, Jurėnas, Dukas, Ostyn, Lisa, Sass, Andrea, Teirlinck, Eline, Van Acker, Heleen, Van Melderen, Laurence   +12 more
core   +1 more source

HigB of Pseudomonas aeruginosa enhances killing of phagocytes by up-regulating the type III secretion system in ciprofloxacin induced persister cells

Frontiers in Cellular and Infection Microbiology, 2016
Bacterial persister cells are dormant and highly tolerant to lethal antibiotics, which are believed to be the major cause of recurring and chronic infections.
Mei Li, Yuqing Long, Ying Liu, Yang Liu, Ronghao Chen, Jing Shi, Lu Zhang, Yongxin Jin, Liang Yang, Liang Yang, Fang Bai, Shouguang Jin, Shouguang Jin, Zhihui Cheng, Weihui Wu   +14 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Toxinome—the bacterial protein toxin database

mBio
Protein toxins are key molecular weapons in biology that are used to attack neighboring cells. Bacteria use protein toxins to kill or inhibit the growth of prokaryotic and eukaryotic cells using various modes of action that target essential cellular ...
Aleks Danov, Ofir Segev, Avi Bograd, Yedidya Ben Eliyahu, Noam Dotan, Tommy Kaplan, Asaf Levy   +6 more
doaj   +1 more source

sRNA Antitoxins: More than One Way to Repress a Toxin

Toxins, 2014
Bacterial toxin-antitoxin loci consist of two genes: one encodes a potentially toxic protein, and the second, an antitoxin to repress its function or expression. The antitoxin can either be an RNA or a protein.
Jia Wen, Elizabeth M. Fozo
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]

, 2014
Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S, Good, L, Hamat, R A, Neela, V, Sadeghifard, N, Sekawi, Z, Soheili, S   +6 more
core   +5 more sources

Glabralysins, potential New β-pore-forming toxin family members from the schistosomiasis vector snail biomphalaria glabrata [PDF]

, 2020
Biomphalaria glabrata is a freshwater Planorbidae snail. In its environment, this mollusk faces numerous microorganisms or pathogens, and has developed sophisticated innate immune mechanisms to survive.
Crickmore, Neil, Duval, David, Galinier, Richard, Gourbal, Benjamin, Lassalle, Damien, Pinaud, Silvain, Tetreau, Guillaume   +6 more
core   +3 more sources

Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.

PLoS Genetics, 2012
Abortive infection, during which an infected bacterial cell commits altruistic suicide to destroy the replicating bacteriophage and protect the clonal population, can be mediated by toxin-antitoxin systems such as the Type III protein-RNA toxin-antitoxin
Tim R Blower, Terry J Evans, Rita Przybilski, Peter C Fineran, George P C Salmond   +4 more
doaj   +1 more source

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS Genetics, 2020
RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology.
Magnus Stårsta, Disa L Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi   +8 more
doaj   +1 more source